FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007273075> ?p ?o ?g. }

• W2007273075 endingPage "317" @default.
• W2007273075 startingPage "312" @default.
• W2007273075 abstract "Uncaria tomentosa, commonly known as cat's claw, is a medicinal plant native to Peru, which has been used for decades in the treatment of various inflammatory disorders. Uncaria tomentosa can be used as an antioxidant, has anti-apoptotic properties, and can enhance DNA repair, however it is best know for its anti-inflammatory properties. Treatment with Uncaria tomentosa extracts inhibits the production of the pro-inflammatory cytokine, TNF-α, which is a critical mediator of the immune response. In this paper, we showed that treatment of THP-1 monocyte-like cells with Uncaria tomentosa extracts inhibited the MAP kinase signaling pathway and altered cytokine expression. Using ELISA assays, we showed that treatment with Uncaria tomentosa extracts augmented LPS-dependent expression of IL-1β by 2.4-fold, while inhibiting the LPS-dependent expression of TNF-α by 5.5-fold. We also showed that treatment of LPS-stimulated THP-1 cells with Uncaria tomentosa extracts blocked ERK1/2 and MEK1/2 phosphorylation in a dose-dependent manner. These data demonstrate that treatment of THP-1 cells with Uncaria tomentosa extracts has opposite effects on IL-1β and TNF-α secretion, and that these changes may involve effects on the MAP kinase pathway." @default.
• W2007273075 created "2016-06-24" @default.
• W2007273075 creator A5014650672 @default.
• W2007273075 creator A5028107605 @default.
• W2007273075 creator A5039420874 @default.
• W2007273075 creator A5042103706 @default.
• W2007273075 creator A5048034601 @default.
• W2007273075 creator A5067205824 @default.
• W2007273075 date "2007-01-01" @default.
• W2007273075 modified "2023-10-01" @default.
• W2007273075 title "Treatment of THP-1 cells with Uncaria tomentosa extracts differentially regulates the expression if IL-1β and TNF-α" @default.
• W2007273075 cites W1481664342 @default.
• W2007273075 cites W1490521893 @default.
• W2007273075 cites W1587198195 @default.
• W2007273075 cites W1973967947 @default.
• W2007273075 cites W198465347 @default.
• W2007273075 cites W2004212929 @default.
• W2007273075 cites W2017487826 @default.
• W2007273075 cites W2028892440 @default.
• W2007273075 cites W2041981966 @default.
• W2007273075 cites W2049660859 @default.
• W2007273075 cites W2051947500 @default.
• W2007273075 cites W2055822131 @default.
• W2007273075 cites W2081932329 @default.
• W2007273075 cites W2087841658 @default.
• W2007273075 cites W2099340589 @default.
• W2007273075 cites W2120710519 @default.
• W2007273075 cites W2125946338 @default.
• W2007273075 cites W2128474659 @default.
• W2007273075 cites W2158998343 @default.
• W2007273075 cites W2159319639 @default.
• W2007273075 cites W2164661350 @default.
• W2007273075 cites W2164717705 @default.
• W2007273075 cites W2169150244 @default.
• W2007273075 cites W241810750 @default.
• W2007273075 cites W54752989 @default.
• W2007273075 doi "https://doi.org/10.1016/j.jep.2006.07.039" @default.
• W2007273075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16959454" @default.
• W2007273075 hasPublicationYear "2007" @default.
• W2007273075 type Work @default.
• W2007273075 sameAs 2007273075 @default.
• W2007273075 citedByCount "54" @default.
• W2007273075 countsByYear W20072730752012 @default.
• W2007273075 countsByYear W20072730752013 @default.
• W2007273075 countsByYear W20072730752014 @default.
• W2007273075 countsByYear W20072730752015 @default.
• W2007273075 countsByYear W20072730752017 @default.
• W2007273075 countsByYear W20072730752018 @default.
• W2007273075 countsByYear W20072730752020 @default.
• W2007273075 countsByYear W20072730752021 @default.
• W2007273075 countsByYear W20072730752022 @default.
• W2007273075 countsByYear W20072730752023 @default.
• W2007273075 crossrefType "journal-article" @default.
• W2007273075 hasAuthorship W2007273075A5014650672 @default.
• W2007273075 hasAuthorship W2007273075A5028107605 @default.
• W2007273075 hasAuthorship W2007273075A5039420874 @default.
• W2007273075 hasAuthorship W2007273075A5042103706 @default.
• W2007273075 hasAuthorship W2007273075A5048034601 @default.
• W2007273075 hasAuthorship W2007273075A5067205824 @default.
• W2007273075 hasConcept C17991360 @default.
• W2007273075 hasConcept C203014093 @default.
• W2007273075 hasConcept C204258353 @default.
• W2007273075 hasConcept C2778690821 @default.
• W2007273075 hasConcept C2781184567 @default.
• W2007273075 hasConcept C54355233 @default.
• W2007273075 hasConcept C556039675 @default.
• W2007273075 hasConcept C71924100 @default.
• W2007273075 hasConcept C81885089 @default.
• W2007273075 hasConcept C86803240 @default.
• W2007273075 hasConcept C8891405 @default.
• W2007273075 hasConcept C98274493 @default.
• W2007273075 hasConceptScore W2007273075C17991360 @default.
• W2007273075 hasConceptScore W2007273075C203014093 @default.
• W2007273075 hasConceptScore W2007273075C204258353 @default.
• W2007273075 hasConceptScore W2007273075C2778690821 @default.
• W2007273075 hasConceptScore W2007273075C2781184567 @default.
• W2007273075 hasConceptScore W2007273075C54355233 @default.
• W2007273075 hasConceptScore W2007273075C556039675 @default.
• W2007273075 hasConceptScore W2007273075C71924100 @default.
• W2007273075 hasConceptScore W2007273075C81885089 @default.
• W2007273075 hasConceptScore W2007273075C86803240 @default.
• W2007273075 hasConceptScore W2007273075C8891405 @default.
• W2007273075 hasConceptScore W2007273075C98274493 @default.
• W2007273075 hasIssue "2" @default.
• W2007273075 hasLocation W20072730751 @default.
• W2007273075 hasLocation W20072730752 @default.
• W2007273075 hasOpenAccess W2007273075 @default.
• W2007273075 hasPrimaryLocation W20072730751 @default.
• W2007273075 hasRelatedWork W1988832250 @default.
• W2007273075 hasRelatedWork W2005546669 @default.
• W2007273075 hasRelatedWork W2043331267 @default.
• W2007273075 hasRelatedWork W2070519352 @default.
• W2007273075 hasRelatedWork W2085322992 @default.
• W2007273075 hasRelatedWork W2136802530 @default.
• W2007273075 hasRelatedWork W2178444743 @default.
• W2007273075 hasRelatedWork W2186743030 @default.
• W2007273075 hasRelatedWork W2784163181 @default.
• W2007273075 hasRelatedWork W345330829 @default.

• next