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- W2007276590 abstract "RECENTLY Fletcher and Huehns1–3 proposed an interesting hypothesis on the possible functional difference between the two iron binding sites of the iron transport protein, transferrin. They presented evidence from in vitro studies that iron uptake by the two binding sites is random, while the release of iron to erythroid precursors occurs preferentially from one site, which they arbitrarily designated the A site. This site is also postulated to be important in the transfer of iron to the placenta of pregnant animals. The other site, designated B, is somehow concerned with delivery of iron to storage depots. Complete saturation of both sites with iron produces greater transfer to erythroid precursors and/or storage depots. The concept of selective release of iron from functionally different binding sites on the transferrin molecule is potentially of great importance and warranted repetition of Fletcher and Huehns's in vitro experiments and the exploration of their hypothesis in vivo." @default.
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- W2007276590 modified "2023-09-27" @default.
- W2007276590 title "In vivo Testing of the Fletcher–Huehns Hypothesis of Functional Differences of Iron Atoms bound by Transferrin" @default.
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- W2007276590 doi "https://doi.org/10.1038/226356a0" @default.
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