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- W2007279871 abstract "<h3>To the Editor.—</h3> The increase in homovanillic acid (HVA) concentration in rat plasma occurring after treatment with neuroleptic drugs has been found to be largely of central nervous system origin,<sup>1</sup>although basal levels derive from both the periphery and the central nervous system.<sup>2</sup>The findings on the effect of neuroleptic drugs on plasma HVA level in humans have not been entirely consistent. Pickar et al<sup>3</sup>failed to demonstrate an acute neuroleptic drug-induced increase in plasma HVA level in schizophrenic patients, and Davis et al<sup>4</sup>originally were unable to detect this effect in subjects studied six hours after treatment. Recently, this latter group reported that an increase did occur 24 hours after treatment.<sup>5</sup>They administered haloperidol intramuscularly at 11 AM (0.2 mg/kg) and later, at 6 PM, orally (10 mg). The level of HVA in plasma was determined before administration of haloperidol and again the next" @default.
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- W2007279871 date "1987-09-01" @default.
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- W2007279871 title "Elevation of Plasma Homovanillic Acid Level Can Be Detected Within Four Hours After Initiation of Haloperidol Treatment" @default.
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- W2007279871 doi "https://doi.org/10.1001/archpsyc.1987.01800210089014" @default.
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