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• W2007280959 abstract "Caffeine and ryanodine triggered an increase in [Ca2+]i (73 +/- 22 and 61 +/- 18 nM, respectively) in Jurkat cell populations that was independent of external Ca2+. In individual cells, caffeine and ryanodine induced Ca2+ spikes. Jurkat cell populations initially exposed to caffeine did not respond further to ryanodine and vice versa, suggesting an overlap of the Ca2+ pool that was contained within the thapsigargin-sensitive Ca2+ reserve. [3H]ryanodine bound to a single class of sites of Jurkat microsomes (KD, 18.4 +/- 5.7 nM; Bmax, 24.3 +/- 7.7 fmol/mg protein). Photolytic release (Nitr5) of caged Ca2+ induced a time-dependent increase of Ca2+ in individual Jurkat cells. The profile of the release of Ca2+ was characterized, 1) by a kinetic (0.55 +/- 0.07 nM s-1) slower than the Ca2+ response to caffeine (3.93 +/- 0.66 nM s-1) or to ryanodine (3.96 +/- 0.94 nM s-1), 2) by a release of Ca2+ (131 +/- 43 nM) that slowly returned to baseline and during which low amplitude oscillations were present (room temperature) or Ca2+ spikes (37 degrees C) and, 3) by a lack of dependency on an influx of Ca2+. Inhibitors of CICR (ruthenium red and 1-octanol) prevented the photolysis-dependent increase in [Ca2+]i but not the InsP3-dependent Ca2+ response. Our data suggest that Jurkat T cells possess at least two Ca2+ pools, one that is sensitive to InsP3 and one that is insensitive. These two Ca2+ pools may be involved in a CICR that generates spontaneous Ca2+ spikes and oscillations in these cells." @default.
• W2007280959 created "2016-06-24" @default.
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• W2007280959 date "1997-02-01" @default.
• W2007280959 modified "2023-09-27" @default.
• W2007280959 title "A Caffeine/Ryanodine-sensitive Ca2+ Pool Is Involved in Triggering Spontaneous Variations of Ca2+ in Jurkat T Lymphocytes by a Ca2+-induced Ca2+ Release (CICR) Mechanism" @default.
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• W2007280959 doi "https://doi.org/10.1016/s0898-6568(96)00141-6" @default.
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