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- W2007288927 abstract "Caspase-1/interleukin-1beta (IL-1beta)-converting enzyme (ICE) cleaves IL-1beta and IL-18 precursor proteins to the active forms of these proinflammatory cytokines. Since both cytokines are constitutively expressed in the brain, we investigated whether this is also the case for caspase-1. Using an antibody raised against the p10-subunit of the active enzyme, constitutive expression of caspase-1 immunoreactivity was found in nerve cells in the arcuate nucleus and in nerve fibres throughout the brain. Co-localisation with alpha-melanocyte stimulating hormone was demonstrated. The distribution pattern of caspase-1 immunoreactive structures is consistent with a role to produce mature IL-1beta in regions where IL-1beta mediates fever and sleep." @default.
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- W2007288927 date "2004-01-01" @default.
- W2007288927 modified "2023-10-16" @default.
- W2007288927 title "Neuronal expression of caspase-1 immunoreactivity in the rat central nervous system" @default.
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- W2007288927 doi "https://doi.org/10.1016/j.jneuroim.2003.10.047" @default.
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