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- W2007289131 abstract "Human B-cell activation was studied in a microculture system, using pokeweed mitogen as a polyclonal activator. The resulting production of IgM, IgG, and IgA in culture supernatants was measured with a radioimmunoassay. Lymphocyte culture conditions were studied with regard to cell number and culture period. The high efficiency of the culture system presented (only 40 × 103 PBL were cultured for 7 days in the presence of PWM) was demonstrated by a comparison of the amounts of IgM, produced in our system, with the amounts reported by other authors, especially when differences in cell numbers were considered. In the present study the IgM production was much higher than in the other systems. Interactions between B and T lymphocytes were investigated in terms of “help” and “suppression.” Suppressor activity could be associated with a subset of T cells, bearing Fc receptors for IgG (Tγ cells), while helper activity was mediated by T cells, lacking Fc receptors for IgG (T non-γ cells). T-helper and -suppressor activity were sensitive to gamma irradiation at doses of resp. 6000 and 3000 rad." @default.
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- W2007289131 date "1981-06-01" @default.
- W2007289131 modified "2023-09-27" @default.
- W2007289131 title "Immunoglobulin production by human lymphocytes in a microculture system: Culture conditions and cellular interactions" @default.
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- W2007289131 doi "https://doi.org/10.1016/0090-1229(81)90077-5" @default.
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