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• W2007292997 abstract "1. The pattern of synaptic activity in lateral gastrocnemius (l.g.) motoneurones in the lumbar spinal cord of chick embryos (Stage 44-45, 19-21 d of incubation) has been examined using intracellular recording. In the motoneurones of normal chick embryos, stimulation of different peripheral, sciatic nerve branches gave rise to characteristic synaptic responses. Stimulation of the lateral gastrocnemius nerve caused a monosynaptic e.p.s.p. which was graded by the intensity of nerve stimulation. Stimulation of synergistic muscle afferents also caused a brief latency e.p.s.p., followed by longer latency excitatory and inhibitory synaptic potentials. Stimulation of antagonistic muscle afferents or cutaneous afferents gave rise to longer latency inhibitory and excitatory synaptic potentials respectively.2. The synaptic activity of l.g. motoneurones was also recorded in embryos in which short segments of the lumbar neural crest had been destroyed by microcautery at 3 d of incubation (Stage 18). The embryos developed without sensory ganglia and dorsal roots in the corresponding region.3. At 19-21 d of incubation, the amplitude of the l.g. e.p.s.p. of l.g. motoneurones in deafferented segments was on the average only a half to a third of the amplitude seen in motoneurones of intact spinal segments. However, both the l.g. and synergist e.p.s.p.s were larger than those seen in acutely deafferented segments of normal embryos.4. In spite of the weak monosynaptic input from l.g. and synergistic afferents, the pattern of synaptic activity evoked by antagonistic muscle afferent or cutaneous afferent stimulation was not different from normal. This was even the case for gastrocnemius motoneurones in which no early e.p.s.p. could be evoked by stimulating the l.g. or synergistic muscle nerves.5. No muscle spindles could be seen in sections of l.g. muscles from embryos with extensive lesions of the lumbosacral neural crest. Incomplete lesions of l.g. segments reduced the number of spindles in the muscle.6. These results suggest that when motoneurones are deprived of part of their normal synaptic input before the formation of peripheral connexions, the identity of the motoneurones (in terms of the origin of their synaptic input) is preserved. Missing synaptic inputs are either replaced by appropriate afferent fibres, if they are available, or not at all. The chick sensory ganglion cells with monosynaptic connexions to motoneurones appear to be unable to compensate significantly for peripheral or central defects in the innervation of the hind limb. They behave as if their developmental possibilities were quite rigidly determined at an early embryonic stage." @default.
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• W2007292997 date "1982-03-01" @default.
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• W2007292997 title "The effect of lesions in the neural crest on the formation of synaptic connexions in the embryonic chick spinal cord" @default.
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• W2007292997 doi "https://doi.org/10.1113/jphysiol.1982.sp014124" @default.
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