FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007303401> ?p ?o ?g. }

• W2007303401 endingPage "19171" @default.
• W2007303401 startingPage "19166" @default.
• W2007303401 abstract "Gene suppression and overexpression are both fundamental tools in linking genotype to phenotype in model organisms. Computational methods have proven invaluable in studying and predicting the deleterious effects of gene deletions, and yet parallel computational methods for overexpression are still lacking. Here, we present Expression-Dependent Gene Effects (EDGE), an in silico method that can predict the deleterious effects resulting from overexpression of either native or foreign metabolic genes. We first test and validate EDGE's predictive power in bacteria through a combination of small-scale growth experiments that we performed and analysis of extant large-scale datasets. Second, a broad cross-species analysis, ranging from microorganisms to multiple plant and human tissues, shows that genes that EDGE predicts to be deleterious when overexpressed are indeed typically down-regulated. This reflects a universal selection force keeping the expression of potentially deleterious genes in check. Third, EDGE-based analysis shows that cancer genetic reprogramming specifically suppresses genes whose overexpression impedes proliferation. The magnitude of this suppression is large enough to enable an almost perfect distinction between normal and cancerous tissues based solely on EDGE results. We expect EDGE to advance our understanding of human pathologies associated with up-regulation of particular transcripts and to facilitate the utilization of gene overexpression in metabolic engineering." @default.
• W2007303401 created "2016-06-24" @default.
• W2007303401 creator A5015777117 @default.
• W2007303401 creator A5018709096 @default.
• W2007303401 creator A5024718393 @default.
• W2007303401 creator A5032824882 @default.
• W2007303401 creator A5063492133 @default.
• W2007303401 creator A5077184904 @default.
• W2007303401 creator A5089647811 @default.
• W2007303401 date "2013-11-06" @default.
• W2007303401 modified "2023-10-11" @default.
• W2007303401 title "Computational evaluation of cellular metabolic costs successfully predicts genes whose expression is deleterious" @default.
• W2007303401 cites W1969983517 @default.
• W2007303401 cites W1978396622 @default.
• W2007303401 cites W1979287129 @default.
• W2007303401 cites W1985090800 @default.
• W2007303401 cites W1989277878 @default.
• W2007303401 cites W1989488173 @default.
• W2007303401 cites W1996629685 @default.
• W2007303401 cites W2009740169 @default.
• W2007303401 cites W2019115334 @default.
• W2007303401 cites W2029403511 @default.
• W2007303401 cites W2030776070 @default.
• W2007303401 cites W2033525264 @default.
• W2007303401 cites W2033828028 @default.
• W2007303401 cites W2048593866 @default.
• W2007303401 cites W2053427298 @default.
• W2007303401 cites W2054506883 @default.
• W2007303401 cites W2061576647 @default.
• W2007303401 cites W2067298056 @default.
• W2007303401 cites W2073265884 @default.
• W2007303401 cites W2074893062 @default.
• W2007303401 cites W2076262841 @default.
• W2007303401 cites W2078355959 @default.
• W2007303401 cites W2082382448 @default.
• W2007303401 cites W2085212480 @default.
• W2007303401 cites W2089194509 @default.
• W2007303401 cites W2090048853 @default.
• W2007303401 cites W2091111800 @default.
• W2007303401 cites W2098390695 @default.
• W2007303401 cites W2098824895 @default.
• W2007303401 cites W2100084634 @default.
• W2007303401 cites W2104108767 @default.
• W2007303401 cites W2109880272 @default.
• W2007303401 cites W2113088269 @default.
• W2007303401 cites W2115928708 @default.
• W2007303401 cites W2120517678 @default.
• W2007303401 cites W2127455737 @default.
• W2007303401 cites W2128985829 @default.
• W2007303401 cites W2130364940 @default.
• W2007303401 cites W2133102806 @default.
• W2007303401 cites W2133556195 @default.
• W2007303401 cites W2133809942 @default.
• W2007303401 cites W2134981469 @default.
• W2007303401 cites W2142145420 @default.
• W2007303401 cites W2147189708 @default.
• W2007303401 cites W2149202606 @default.
• W2007303401 cites W2150187794 @default.
• W2007303401 cites W2152186196 @default.
• W2007303401 cites W2153056550 @default.
• W2007303401 cites W2154767435 @default.
• W2007303401 cites W2157149907 @default.
• W2007303401 cites W2159022315 @default.
• W2007303401 cites W2160079005 @default.
• W2007303401 cites W2160541874 @default.
• W2007303401 cites W2163240970 @default.
• W2007303401 cites W2164293128 @default.
• W2007303401 cites W2164683872 @default.
• W2007303401 cites W2165335121 @default.
• W2007303401 cites W2167228645 @default.
• W2007303401 cites W2168258419 @default.
• W2007303401 cites W2170023904 @default.
• W2007303401 cites W2170427655 @default.
• W2007303401 cites W4256259619 @default.
• W2007303401 doi "https://doi.org/10.1073/pnas.1312361110" @default.
• W2007303401 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3839766" @default.
• W2007303401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24198337" @default.
• W2007303401 hasPublicationYear "2013" @default.
• W2007303401 type Work @default.
• W2007303401 sameAs 2007303401 @default.
• W2007303401 citedByCount "19" @default.
• W2007303401 countsByYear W20073034012014 @default.
• W2007303401 countsByYear W20073034012015 @default.
• W2007303401 countsByYear W20073034012016 @default.
• W2007303401 countsByYear W20073034012017 @default.
• W2007303401 countsByYear W20073034012021 @default.
• W2007303401 countsByYear W20073034012022 @default.
• W2007303401 crossrefType "journal-article" @default.
• W2007303401 hasAuthorship W2007303401A5015777117 @default.
• W2007303401 hasAuthorship W2007303401A5018709096 @default.
• W2007303401 hasAuthorship W2007303401A5024718393 @default.
• W2007303401 hasAuthorship W2007303401A5032824882 @default.
• W2007303401 hasAuthorship W2007303401A5063492133 @default.
• W2007303401 hasAuthorship W2007303401A5077184904 @default.
• W2007303401 hasAuthorship W2007303401A5089647811 @default.
• W2007303401 hasBestOaLocation W20073034011 @default.
• W2007303401 hasConcept C104317684 @default.
• W2007303401 hasConcept C127716648 @default.

• next