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- W2007304876 abstract "The electroreduction of chloramphenicol has been studied by polarography, cyclic voltammetry, chronopotentiometry and coulometry. The experimental results lead to the conclusion that the drug undergoes a slow 2-electron reduction of the nitro group which is followed by a fast 2-electron reduction to hydroxylamine. At more negative potentials the hydroxylamine group is further reduced to the amine. In acetate buffer pH 4.7 with 0.003 % decylamine present, the drug produces a very well-defined, diffusion-controlled 4-electron polarographic wave. The current is proportional to the concentration and permits the drug to be determined by polarography in the concentration range 0.3–600 μg ml-1. A rapid polarographic method for the determination of chloramphenicol in milk is proposed. Une étude est effectuée sur l'électroréduction du chloramphénicol, par polarographie, voltammétrie cyclique, chronopotentiométrie et coulométrie. Les résultats expérimentaux conduisont à la conclusion qu'il se produit une réduction lente (à 2 électrons) du groupe nitro, suivie d'une réduction rapide (à 2 électrons) en hydroxylamine. Le groupe hydroxylamine est ensuite réduit en amine à des potentiels plus négatifs. Un dosage polarographique est proposé, en milieu tampon pH 4.7, avec 0.003% de décylamine, pour des concentrations de 0.3 à 600 μg ml-1, en particulier dans le lait. Die elektrochemische Reduktion von Chloramphenicol wurde durch Polarographie, cyclische Voltammetrie, Chronopotentiometrie und Coulometrie untersucht. Aus den experimentellen Ergebnissen ist zu schliessen, dass das Arzneimittel einer langsamen 2-Elektronenreduktion der Nitrogruppe unterliegt, auf die eine schnelle 2-Elektronenreduktion zum Hydroxylamin folgt. Bei negativeren Potentialen wird die Hydroxylamingruppe weiter zum Amin reduziert. In Acetatpuffer pH 4.7 mit einem Gehalt von 0.003% Decylamin ruft das Mittel eine sehr gut definierte, diffusionskontrollierte polarographische 4-Elektronenstufe hervor. Der Strom ist der Konzentration proportional und erlaubt die Bestimmung des Arzneimittels durch Polarographie im Konzentrationsbereich 0.3–600 μg ml-1. Eine rapidpolarographische Methode für die Bestimmung von Chloramphenicol in Milch wird vorgeschlagen." @default.
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- W2007304876 date "1971-08-01" @default.
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- W2007304876 title "Polarographic determination of chloramphenicol" @default.
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- W2007304876 doi "https://doi.org/10.1016/s0003-2670(01)80114-8" @default.
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