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• W2007304890 abstract "Neutrophils are involved in the early stages of immune responses to pathogens. Here, we investigated the role of neutrophils during the establishment of Leishmania amazonensis infection in BALB/c and C57BL/6 mice. First, we showed an accumulation of neutrophils between 6 and 24 h post-infection, followed by a reduction in neutrophil numbers after 72 h. Next, we depleted neutrophils prior to infection using RB6-8C5 or 1A8 mAb. Neutrophil depletion led to faster lesion development, increased parasite numbers and higher arginase activity during the first week of infection in BALB/c mice, but not in C57BL/6 mice. Increased susceptibility was accompanied by augmented levels of anti-L. amazonensis IgG and increased production of IL-10 and IL-17. Because IL-10 is a mediator of susceptibility to Leishmania infection, we blocked IL-10 signalling in neutrophil-depleted mice using anti-IL-10R. Interestingly, inhibition of IL-10 signalling abrogated the increase in parasite loads observed in neutrophil-depleted mice, suggesting that parasite proliferation is at least partially mediated by IL-10. Additionally, we tested the effect of IL-17 in inflammatory macrophages and observed that IL-17 increased arginase activity and favoured parasite growth. Taken together, our data indicate that neutrophils control parasite numbers and limit lesion development during the first week of infection in BALB/c mice." @default.
• W2007304890 created "2016-06-24" @default.
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• W2007304890 date "2013-12-09" @default.
• W2007304890 modified "2023-10-18" @default.
• W2007304890 title "Neutrophils have a protective role during early stages of<i>Leishmania amazonensis</i>infection in BALB/c mice" @default.
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• W2007304890 doi "https://doi.org/10.1111/pim.12078" @default.
• W2007304890 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4307027" @default.
• W2007304890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24102495" @default.
• W2007304890 hasPublicationYear "2013" @default.
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