FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007305532> ?p ?o ?g. }

• W2007305532 endingPage "1405" @default.
• W2007305532 startingPage "1401" @default.
• W2007305532 abstract "We propose a quantitative model for T-cell activation in which the rate of dissociation of ligand from T-cell receptors determines the agonist and antagonist properties of the ligand. The ligands are molecular complexes between antigenic peptides and proteins of the major histocompatibility complex on the surfaces of antigen-presenting cells. Binding of ligand to receptor triggers a series of biochemical reactions in the T cell. If the ligand dissociates after these reactions are complete, the T cell receives a positive activation signal. However, dissociation of ligand after completion of the first reaction but prior to generation of the final products results in partial T-cell activation, which acts to suppress a positive response. Such a negative signal is brought about by T-cell ligands containing the variants of antigenic peptides referred to as T-cell receptor antagonists. Results of recent experiments with altered peptide ligands compare favorably with T-cell responses predicted by this model." @default.
• W2007305532 created "2016-06-24" @default.
• W2007305532 creator A5025539602 @default.
• W2007305532 creator A5035511647 @default.
• W2007305532 creator A5041639297 @default.
• W2007305532 creator A5053467552 @default.
• W2007305532 creator A5082611786 @default.
• W2007305532 date "1996-02-20" @default.
• W2007305532 modified "2023-10-14" @default.
• W2007305532 title "Kinetic discrimination in T-cell activation." @default.
• W2007305532 cites W1595789911 @default.
• W2007305532 cites W1959677146 @default.
• W2007305532 cites W1966598940 @default.
• W2007305532 cites W1975807928 @default.
• W2007305532 cites W1980180430 @default.
• W2007305532 cites W1981621164 @default.
• W2007305532 cites W1983612134 @default.
• W2007305532 cites W1991972957 @default.
• W2007305532 cites W1998415250 @default.
• W2007305532 cites W1999436383 @default.
• W2007305532 cites W2009611610 @default.
• W2007305532 cites W2011352102 @default.
• W2007305532 cites W2021922884 @default.
• W2007305532 cites W2031482359 @default.
• W2007305532 cites W2032169064 @default.
• W2007305532 cites W2034169577 @default.
• W2007305532 cites W2035960239 @default.
• W2007305532 cites W2043493614 @default.
• W2007305532 cites W2044009370 @default.
• W2007305532 cites W2046901206 @default.
• W2007305532 cites W2048159226 @default.
• W2007305532 cites W2050989136 @default.
• W2007305532 cites W2059637973 @default.
• W2007305532 cites W2062619192 @default.
• W2007305532 cites W2063695575 @default.
• W2007305532 cites W2064888792 @default.
• W2007305532 cites W2068494547 @default.
• W2007305532 cites W2071423255 @default.
• W2007305532 cites W2074059194 @default.
• W2007305532 cites W2074173506 @default.
• W2007305532 cites W2074616759 @default.
• W2007305532 cites W2078494443 @default.
• W2007305532 cites W2078523699 @default.
• W2007305532 cites W2095433140 @default.
• W2007305532 cites W2099675490 @default.
• W2007305532 cites W2122236783 @default.
• W2007305532 cites W2136613244 @default.
• W2007305532 cites W4231014363 @default.
• W2007305532 doi "https://doi.org/10.1073/pnas.93.4.1401" @default.
• W2007305532 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/39950" @default.
• W2007305532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8643643" @default.
• W2007305532 hasPublicationYear "1996" @default.
• W2007305532 type Work @default.
• W2007305532 sameAs 2007305532 @default.
• W2007305532 citedByCount "278" @default.
• W2007305532 countsByYear W20073055322012 @default.
• W2007305532 countsByYear W20073055322013 @default.
• W2007305532 countsByYear W20073055322014 @default.
• W2007305532 countsByYear W20073055322015 @default.
• W2007305532 countsByYear W20073055322016 @default.
• W2007305532 countsByYear W20073055322017 @default.
• W2007305532 countsByYear W20073055322018 @default.
• W2007305532 countsByYear W20073055322019 @default.
• W2007305532 countsByYear W20073055322020 @default.
• W2007305532 countsByYear W20073055322021 @default.
• W2007305532 countsByYear W20073055322022 @default.
• W2007305532 countsByYear W20073055322023 @default.
• W2007305532 crossrefType "journal-article" @default.
• W2007305532 hasAuthorship W2007305532A5025539602 @default.
• W2007305532 hasAuthorship W2007305532A5035511647 @default.
• W2007305532 hasAuthorship W2007305532A5041639297 @default.
• W2007305532 hasAuthorship W2007305532A5053467552 @default.
• W2007305532 hasAuthorship W2007305532A5082611786 @default.
• W2007305532 hasBestOaLocation W20073055322 @default.
• W2007305532 hasConcept C116569031 @default.
• W2007305532 hasConcept C12554922 @default.
• W2007305532 hasConcept C147483822 @default.
• W2007305532 hasConcept C1491633281 @default.
• W2007305532 hasConcept C170493617 @default.
• W2007305532 hasConcept C185592680 @default.
• W2007305532 hasConcept C19317047 @default.
• W2007305532 hasConcept C203014093 @default.
• W2007305532 hasConcept C207936829 @default.
• W2007305532 hasConcept C2776090121 @default.
• W2007305532 hasConcept C2778938600 @default.
• W2007305532 hasConcept C55493867 @default.
• W2007305532 hasConcept C86803240 @default.
• W2007305532 hasConcept C8891405 @default.
• W2007305532 hasConcept C95444343 @default.
• W2007305532 hasConceptScore W2007305532C116569031 @default.
• W2007305532 hasConceptScore W2007305532C12554922 @default.
• W2007305532 hasConceptScore W2007305532C147483822 @default.
• W2007305532 hasConceptScore W2007305532C1491633281 @default.
• W2007305532 hasConceptScore W2007305532C170493617 @default.
• W2007305532 hasConceptScore W2007305532C185592680 @default.
• W2007305532 hasConceptScore W2007305532C19317047 @default.
• W2007305532 hasConceptScore W2007305532C203014093 @default.
• W2007305532 hasConceptScore W2007305532C207936829 @default.

• next