FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007312062> ?p ?o ?g. }

• W2007312062 endingPage "570" @default.
• W2007312062 startingPage "561" @default.
• W2007312062 abstract "Administration of the multipotent hematopoietic progenitor cell (HPC) line DKmix improved cardiac function after myocardial infarction and accelerated dermal wound healing due to paracrine mechanisms. The aim of this study was to analyse the secreted proteins of DKmix cells in order to identify the responsible paracrine factors and assess their relevance to the wide spectrum of therapeutic effects. A mass spectrometry (MS)-based approach was used to identify secreted proteins of DKmix cells. Serum free culture supernatants of DKmix-conditioned medium were collected and the proteins present were separated, digested by trypsin and the resulting peptides were then analyzed by matrix-assisted laser desorption/ionization tandem time-of-flight (MALDI-TOF/TOF) MS. Overall 95 different proteins were identified. Among them, secretory proteins galectin-3 and gelsolin were identified. These proteins are known to stimulate cell migration and influence wound healing and cardiac remodelling. The remaining proteins originate from intracellular compartments like cytoplasm (69%), nucleus (12%), mitochondria (4%), and cytoplasmic membrane (3%) indicating permeable or leaky DKmix cells in the conditioned medium. Additionally, a sandwich immunoassay was used to detect and quantify cytokines and chemokines. Interleukin-6 (IL-6), interleukin-13 (IL-13), monocyte-chemoattractant protein-1 (MCP-1), monocyte-chemoattractant protein-3 (MCP-3), monocyte-chemoattractant protein-1alpha (MIP-1alpha) and monocyte-chemoattractant protein-1beta (MIP-1beta) were detected in low concentrations. This study identified a subset of proteins present in the DKmix-conditioned medium that act as paracrine modulators of tissue repair. Moreover, it suggests that DKmix-derived conditioned medium might have therapeutic potency by promoting tissue regeneration." @default.
• W2007312062 created "2016-06-24" @default.
• W2007312062 creator A5001666794 @default.
• W2007312062 creator A5005331384 @default.
• W2007312062 creator A5038812871 @default.
• W2007312062 creator A5044768118 @default.
• W2007312062 creator A5066672628 @default.
• W2007312062 creator A5086891437 @default.
• W2007312062 date "2010-03-15" @default.
• W2007312062 modified "2023-09-27" @default.
• W2007312062 title "Secreted proteome of the murine multipotent hematopoietic progenitor cell line DKmix" @default.
• W2007312062 cites W1508165289 @default.
• W2007312062 cites W1970979847 @default.
• W2007312062 cites W1972257177 @default.
• W2007312062 cites W1972345464 @default.
• W2007312062 cites W1978859651 @default.
• W2007312062 cites W1982236738 @default.
• W2007312062 cites W1986415053 @default.
• W2007312062 cites W2002505824 @default.
• W2007312062 cites W2006499389 @default.
• W2007312062 cites W2006986579 @default.
• W2007312062 cites W2013636193 @default.
• W2007312062 cites W2014097940 @default.
• W2007312062 cites W2014189665 @default.
• W2007312062 cites W2026315775 @default.
• W2007312062 cites W2030141485 @default.
• W2007312062 cites W2035676423 @default.
• W2007312062 cites W2056666997 @default.
• W2007312062 cites W2058676872 @default.
• W2007312062 cites W2075344844 @default.
• W2007312062 cites W2075572162 @default.
• W2007312062 cites W2077731013 @default.
• W2007312062 cites W2093192099 @default.
• W2007312062 cites W2094558882 @default.
• W2007312062 cites W2099111992 @default.
• W2007312062 cites W2100837269 @default.
• W2007312062 cites W2111486034 @default.
• W2007312062 cites W2111883347 @default.
• W2007312062 cites W2112267683 @default.
• W2007312062 cites W2113436661 @default.
• W2007312062 cites W2124396531 @default.
• W2007312062 cites W2128553876 @default.
• W2007312062 cites W2133226946 @default.
• W2007312062 cites W2135920231 @default.
• W2007312062 cites W2143492218 @default.
• W2007312062 cites W2151722542 @default.
• W2007312062 cites W2152204206 @default.
• W2007312062 cites W2154935039 @default.
• W2007312062 cites W2165721689 @default.
• W2007312062 cites W2333967939 @default.
• W2007312062 cites W4293247451 @default.
• W2007312062 doi "https://doi.org/10.1002/rcm.4412" @default.
• W2007312062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20127908" @default.
• W2007312062 hasPublicationYear "2010" @default.
• W2007312062 type Work @default.
• W2007312062 sameAs 2007312062 @default.
• W2007312062 citedByCount "11" @default.
• W2007312062 countsByYear W20073120622012 @default.
• W2007312062 countsByYear W20073120622014 @default.
• W2007312062 countsByYear W20073120622015 @default.
• W2007312062 crossrefType "journal-article" @default.
• W2007312062 hasAuthorship W2007312062A5001666794 @default.
• W2007312062 hasAuthorship W2007312062A5005331384 @default.
• W2007312062 hasAuthorship W2007312062A5038812871 @default.
• W2007312062 hasAuthorship W2007312062A5044768118 @default.
• W2007312062 hasAuthorship W2007312062A5066672628 @default.
• W2007312062 hasAuthorship W2007312062A5086891437 @default.
• W2007312062 hasBestOaLocation W20073120622 @default.
• W2007312062 hasConcept C104397665 @default.
• W2007312062 hasConcept C13373296 @default.
• W2007312062 hasConcept C170493617 @default.
• W2007312062 hasConcept C185592680 @default.
• W2007312062 hasConcept C201750760 @default.
• W2007312062 hasConcept C203014093 @default.
• W2007312062 hasConcept C2781184567 @default.
• W2007312062 hasConcept C28328180 @default.
• W2007312062 hasConcept C55493867 @default.
• W2007312062 hasConcept C7876069 @default.
• W2007312062 hasConcept C86803240 @default.
• W2007312062 hasConcept C95444343 @default.
• W2007312062 hasConceptScore W2007312062C104397665 @default.
• W2007312062 hasConceptScore W2007312062C13373296 @default.
• W2007312062 hasConceptScore W2007312062C170493617 @default.
• W2007312062 hasConceptScore W2007312062C185592680 @default.
• W2007312062 hasConceptScore W2007312062C201750760 @default.
• W2007312062 hasConceptScore W2007312062C203014093 @default.
• W2007312062 hasConceptScore W2007312062C2781184567 @default.
• W2007312062 hasConceptScore W2007312062C28328180 @default.
• W2007312062 hasConceptScore W2007312062C55493867 @default.
• W2007312062 hasConceptScore W2007312062C7876069 @default.
• W2007312062 hasConceptScore W2007312062C86803240 @default.
• W2007312062 hasConceptScore W2007312062C95444343 @default.
• W2007312062 hasIssue "5" @default.
• W2007312062 hasLocation W20073120621 @default.
• W2007312062 hasLocation W20073120622 @default.
• W2007312062 hasLocation W20073120623 @default.
• W2007312062 hasOpenAccess W2007312062 @default.
• W2007312062 hasPrimaryLocation W20073120621 @default.

• next