FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007318006> ?p ?o ?g. }

• W2007318006 endingPage "1393" @default.
• W2007318006 startingPage "1384" @default.
• W2007318006 abstract "Ubiquitin-specific proteases (USPs) are a subclass of cysteine proteases that catalyze the removal of ubiquitin (either monomeric or chains) from substrates, thus counteracting the activity of E3 ubiquitin ligases. Although the importance of USPs in a multitude of processes, from hereditary cancer to neurodegeneration, is well established, our knowledge on their mode of regulation, substrate specificity and biological function is quite limited. In this study we identify USP47 as a novel interactor of the E3 ubiquitin ligase, Skp1/Cul1/F-box protein β-transducin repeat-containing protein (SCFβ-Trcp). We found that both β-Trcp1 and β-Trcp2 bind specifically to USP47, and point mutations in the β-Trcp WD-repeat region completely abolished USP47 binding, indicating an E3-substrate-type interaction. However, unlike canonical β-Trcp substrates, USP47 protein levels were neither affected by silencing of β-Trcp nor modulated in a variety of processes, such as cell-cycle progression, DNA damage checkpoint responses or tumor necrosis factor (TNF) pathway activation. Notably, genetic or siRNA-mediated depletion of USP47 induced accumulation of Cdc25A, decreased cell survival and augmented the cytotoxic effects of anticancer drugs. In conclusion, we showed that USP47, a novel β-Trcp interactor, regulates cell growth and survival, potentially providing a novel target for anticancer therapies." @default.
• W2007318006 created "2016-06-24" @default.
• W2007318006 creator A5034919044 @default.
• W2007318006 creator A5043072893 @default.
• W2007318006 creator A5043359170 @default.
• W2007318006 creator A5088089055 @default.
• W2007318006 date "2009-12-07" @default.
• W2007318006 modified "2023-10-17" @default.
• W2007318006 title "The ubiquitin-specific protease USP47 is a novel β-TRCP interactor regulating cell survival" @default.
• W2007318006 cites W1590721859 @default.
• W2007318006 cites W1597871117 @default.
• W2007318006 cites W1852163795 @default.
• W2007318006 cites W1969210627 @default.
• W2007318006 cites W1970111367 @default.
• W2007318006 cites W1970430170 @default.
• W2007318006 cites W1979799592 @default.
• W2007318006 cites W1981916517 @default.
• W2007318006 cites W1988780457 @default.
• W2007318006 cites W2013317474 @default.
• W2007318006 cites W2020235979 @default.
• W2007318006 cites W2033228162 @default.
• W2007318006 cites W2039193100 @default.
• W2007318006 cites W2043798682 @default.
• W2007318006 cites W2046691565 @default.
• W2007318006 cites W2059971436 @default.
• W2007318006 cites W2061156149 @default.
• W2007318006 cites W2062219923 @default.
• W2007318006 cites W2064256444 @default.
• W2007318006 cites W2067343115 @default.
• W2007318006 cites W2068945536 @default.
• W2007318006 cites W2075135229 @default.
• W2007318006 cites W2087092058 @default.
• W2007318006 cites W2088724822 @default.
• W2007318006 cites W2093831890 @default.
• W2007318006 cites W2095424116 @default.
• W2007318006 cites W2108672601 @default.
• W2007318006 cites W2109998847 @default.
• W2007318006 cites W2117620907 @default.
• W2007318006 cites W2123474135 @default.
• W2007318006 cites W2143715819 @default.
• W2007318006 cites W2147291971 @default.
• W2007318006 cites W2148561037 @default.
• W2007318006 cites W2153708110 @default.
• W2007318006 cites W2166761147 @default.
• W2007318006 cites W2166987747 @default.
• W2007318006 cites W2171961817 @default.
• W2007318006 cites W2762075333 @default.
• W2007318006 doi "https://doi.org/10.1038/onc.2009.430" @default.
• W2007318006 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3869786" @default.
• W2007318006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19966869" @default.
• W2007318006 hasPublicationYear "2009" @default.
• W2007318006 type Work @default.
• W2007318006 sameAs 2007318006 @default.
• W2007318006 citedByCount "70" @default.
• W2007318006 countsByYear W20073180062012 @default.
• W2007318006 countsByYear W20073180062013 @default.
• W2007318006 countsByYear W20073180062014 @default.
• W2007318006 countsByYear W20073180062015 @default.
• W2007318006 countsByYear W20073180062016 @default.
• W2007318006 countsByYear W20073180062017 @default.
• W2007318006 countsByYear W20073180062018 @default.
• W2007318006 countsByYear W20073180062019 @default.
• W2007318006 countsByYear W20073180062020 @default.
• W2007318006 countsByYear W20073180062021 @default.
• W2007318006 countsByYear W20073180062022 @default.
• W2007318006 countsByYear W20073180062023 @default.
• W2007318006 crossrefType "journal-article" @default.
• W2007318006 hasAuthorship W2007318006A5034919044 @default.
• W2007318006 hasAuthorship W2007318006A5043072893 @default.
• W2007318006 hasAuthorship W2007318006A5043359170 @default.
• W2007318006 hasAuthorship W2007318006A5088089055 @default.
• W2007318006 hasBestOaLocation W20073180061 @default.
• W2007318006 hasConcept C104317684 @default.
• W2007318006 hasConcept C131312102 @default.
• W2007318006 hasConcept C134459356 @default.
• W2007318006 hasConcept C1491633281 @default.
• W2007318006 hasConcept C166998942 @default.
• W2007318006 hasConcept C181199279 @default.
• W2007318006 hasConcept C182220744 @default.
• W2007318006 hasConcept C25602115 @default.
• W2007318006 hasConcept C2775868145 @default.
• W2007318006 hasConcept C2908868211 @default.
• W2007318006 hasConcept C29537977 @default.
• W2007318006 hasConcept C55493867 @default.
• W2007318006 hasConcept C86803240 @default.
• W2007318006 hasConcept C95444343 @default.
• W2007318006 hasConceptScore W2007318006C104317684 @default.
• W2007318006 hasConceptScore W2007318006C131312102 @default.
• W2007318006 hasConceptScore W2007318006C134459356 @default.
• W2007318006 hasConceptScore W2007318006C1491633281 @default.
• W2007318006 hasConceptScore W2007318006C166998942 @default.
• W2007318006 hasConceptScore W2007318006C181199279 @default.
• W2007318006 hasConceptScore W2007318006C182220744 @default.
• W2007318006 hasConceptScore W2007318006C25602115 @default.
• W2007318006 hasConceptScore W2007318006C2775868145 @default.
• W2007318006 hasConceptScore W2007318006C2908868211 @default.
• W2007318006 hasConceptScore W2007318006C29537977 @default.
• W2007318006 hasConceptScore W2007318006C55493867 @default.

• next