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- W2007321017 abstract "The putative contribution of brain acetaldehyde (AcH) to ethanol (EtOH) tolerance and dependence (addiction) is reviewed. Although the role of AcH in EtOH addiction has been controversial, there are data showing a relationship. AcH can be formed in the brain tissues through the peroxidatic activity of catalase and by oxidation via other oxidizing enzymes such as cytochrome P-4502E1. Significant formation of AcH occurs in vitro in brain tissue at concentrations of EtOH that can be achieved by voluntary consumption of EtOH by rodents. AcH itself possesses reinforcing properties, which suggests that some of the behavioral pharmacological effects attributed to EtOH may be a result of the formation of AcH, and supports the involvement of AcH in EtOH addiction. Modulation of aldehyde dehydrogenase (ALDH) and brain catalase activity can change EtOH-related addictive behaviors presumably by changing AcH levels. Moreover, some condensation reaction products of AcH may promote some actions of EtOH and its consumption. On the basis of the findings, it can be concluded that AcH may mediate some of the CNS actions of EtOH including tolerance and dependence, although further exploration the involvement of AcH in EtOH addiction is warranted." @default.
- W2007321017 created "2016-06-24" @default.
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- W2007321017 date "2008-01-01" @default.
- W2007321017 modified "2023-09-30" @default.
- W2007321017 title "Putative Role of Brain Acetaldehyde in Ethanol Addiction" @default.
- W2007321017 cites W1276362982 @default.
- W2007321017 cites W1573545768 @default.
- W2007321017 cites W19123000 @default.
- W2007321017 cites W1934227057 @default.
- W2007321017 cites W1967169925 @default.
- W2007321017 cites W1967870186 @default.
- W2007321017 cites W1970756197 @default.
- W2007321017 cites W1972609199 @default.
- W2007321017 cites W1973953217 @default.
- W2007321017 cites W1974166079 @default.
- W2007321017 cites W1977289860 @default.
- W2007321017 cites W1978987336 @default.
- W2007321017 cites W1980890656 @default.
- W2007321017 cites W1981965642 @default.
- W2007321017 cites W1983414928 @default.
- W2007321017 cites W1984166533 @default.
- W2007321017 cites W1989348547 @default.
- W2007321017 cites W1989463289 @default.
- W2007321017 cites W1991524232 @default.
- W2007321017 cites W1994390109 @default.
- W2007321017 cites W1996081904 @default.
- W2007321017 cites W1998054220 @default.
- W2007321017 cites W2003515652 @default.
- W2007321017 cites W2004918479 @default.
- W2007321017 cites W2005886866 @default.
- W2007321017 cites W2006583291 @default.
- W2007321017 cites W2008478633 @default.
- W2007321017 cites W2012587742 @default.
- W2007321017 cites W2016232653 @default.
- W2007321017 cites W2016975502 @default.
- W2007321017 cites W2024258467 @default.
- W2007321017 cites W2025065453 @default.
- W2007321017 cites W2028750532 @default.
- W2007321017 cites W2030813390 @default.
- W2007321017 cites W2033604860 @default.
- W2007321017 cites W2036977803 @default.
- W2007321017 cites W2039886294 @default.
- W2007321017 cites W2042778689 @default.
- W2007321017 cites W2042980702 @default.
- W2007321017 cites W2048696071 @default.
- W2007321017 cites W2052362668 @default.
- W2007321017 cites W2053728845 @default.
- W2007321017 cites W2053851707 @default.
- W2007321017 cites W2057644086 @default.
- W2007321017 cites W2063389076 @default.
- W2007321017 cites W2063510212 @default.
- W2007321017 cites W2065605836 @default.
- W2007321017 cites W2067793168 @default.
- W2007321017 cites W2068776195 @default.
- W2007321017 cites W2069642921 @default.
- W2007321017 cites W2080714744 @default.
- W2007321017 cites W2084981345 @default.
- W2007321017 cites W2085307854 @default.
- W2007321017 cites W2087482466 @default.
- W2007321017 cites W2090132220 @default.
- W2007321017 cites W2091162455 @default.
- W2007321017 cites W2093172763 @default.
- W2007321017 cites W2093328584 @default.
- W2007321017 cites W2104193035 @default.
- W2007321017 cites W2114045252 @default.
- W2007321017 cites W2114826292 @default.
- W2007321017 cites W2122742102 @default.
- W2007321017 cites W2133056952 @default.
- W2007321017 cites W2151229899 @default.
- W2007321017 cites W2153131480 @default.
- W2007321017 cites W2159820972 @default.
- W2007321017 cites W2163814494 @default.
- W2007321017 cites W2164051909 @default.
- W2007321017 cites W2170564447 @default.
- W2007321017 cites W2287362453 @default.
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- W2007321017 doi "https://doi.org/10.2174/1874473710801010003" @default.
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