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- W2007332015 abstract "The effects of a K+ channel blocker, bisG10, were examined on ATP-sensitive K+ (KATP) channels in membrane patches excised from mammalian and amphibian skeletal muscle fibres using the patch-clamp technique. At micromolar concentrations, bisG10, added on the intracellular side, induced a strong, reversible, flickery block of KATP channels. BisG10, added on the extracellular side, was about 100-fold less potent at inhibiting channel activity. At 10 nM, intracellular bisG10 increased KATP channel activity. This activation was independent of the presence of internal ATP or Mg2+. The inhibitory effect of bisG10 most likely arose from open-channel block whereas activation could result from more complex, indirect interactions." @default.
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- W2007332015 date "1995-11-20" @default.
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- W2007332015 title "Dose-dependent activation and block by bisG10, a K+channel blocker, of mouse and frog skeletal muscle KATPchannels" @default.
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- W2007332015 doi "https://doi.org/10.1016/0014-5793(95)01217-3" @default.
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