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• W2007335401 abstract "1,3,5-Trinitrobenzene (TNB) is a munitions chemical that causes gliovascular lesions in the brain stem of rats similar to those produced by thiamine deficiency and nitroaromatic compounds, including m-dinitrobenzene. To identify neuropathic indices of toxicity, the effects of varying concentrations (0 to 2 mM) of TNB on cytotoxicity and cellular metabolic activity were examined using cultured astrocytes from Fischer-344 rats. The cytotoxicity was assessed by lactate dehydrogenase (LDH) leakage into the culture medium. Astrocyte metabolic activity was assessed by measuring the conversion of a tetrazolium salt to a formazan product. Additionally, the effects of oxidative stress on cellular metabolic activity - were determined by varying oxygen tension via alteration of culture media depth. In vitro, the toxic concentration 50% (TC 50 ) of TNB, which induced cell death, was 16 μM following a 24-h exposure. The concentration of TNB that reduced cellular metabolic activity by 50% was 29 μM following a 24-h exposure. Varying the depth of the culture media did not influence the cellular metabolic activity in control or TNB-treated astrocytes. These results support the hypothesis that TNB induced neurotoxicity could partially be mediated via injury to astrocytes, a major component of the blood-brain barrier." @default.
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• W2007335401 date "2005-01-01" @default.
• W2007335401 modified "2023-10-16" @default.
• W2007335401 title "Effects of 1,3,5-Trinitrobenzene on Cytotoxicity and Metabolic Activity of Type I Astrocytes of Rats" @default.
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• W2007335401 doi "https://doi.org/10.1080/10915810590918724" @default.
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