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- W2007341630 abstract "Abstract Vitamin D , an immunomodulator of macrophage function, can activate human antimycobacterial activity. Vitamin D deficiency ( VDD ) is associated with an impaired mycobacterial immunity and susceptibility to tuberculosis. It has been found that vitamin D and its receptor may be essential for immune function. In this study, we examined the serum 25( OH ) vitamin D levels and its receptor ( VDR ) polymorphisms with susceptibility to tuberculosis in patients, household contacts and healthy controls. Serum 25( OH ) vitamin D levels were measured in 75 cases (25 patients, 25 household contacts and 25 healthy controls), and polymorphisms ( B sm I and F ok I ) were carried out in 335 cases (110 patients, 110 household contacts and 115 healthy controls). The proportion of serum 25( OH ) vitamin D deficiency and insufficiency was high in patients (44, 58%) and household contacts (40, 48%) compared to controls (48%). The BB and B b genotypes of B sm I were significantly associated in patients ( P < 0.014; OR : 0.509; CI : 0.265–0.876) ( P < 0.001; OR : 2.351; CI : 1.368–4.041) and household contacts ( P < 0.04; OR : 0.575; CI : 0.336–0.985); ( P < 0.002; OR : −2.267; CI : 1.32–3.895) when compared to healthy controls. The diplotype and MDR analysis showed the high‐risk genotypes of B sm I and F ok I polymorphisms. Vitamin D deficiency and its association with VDR gene polymorphisms may be useful to identify the high‐risk group individuals." @default.
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- W2007341630 date "2014-01-23" @default.
- W2007341630 modified "2023-10-03" @default.
- W2007341630 title "Serum Vitamin D Levels and VDR Polymorphisms (BsmI and FokI) in Patients and their Household Contacts Susceptible to Tuberculosis" @default.
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- W2007341630 doi "https://doi.org/10.1111/sji.12127" @default.
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