Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007342138> ?p ?o ?g. }
- W2007342138 endingPage "340" @default.
- W2007342138 startingPage "336" @default.
- W2007342138 abstract "Myocardial ischemia and reperfusion (MI/R) is associated with an intense inflammatory reaction, which may lead to myocyte injury. Because statins protect the myocardium against ischemia-reperfusion injury via a mechanism unrelated to cholesterol lowering, we hypothesized that the protective effect of statins was related to the expression of TNF-alpha (TNF-alpha) and interleukin-10 (IL-10) mRNA. Seventy-two rats were randomly divided into three groups as follows: sham, I/R and I/R+atorvastatin. Atorvastatin (20 mg kg(-1)day(-1)) treatment was administered daily via oral gavage to rats for 2, 7 or 14 days. Ischemia was induced via a 30-min coronary occlusion. Reperfusion was allowed until 2, 7 or 14 days while atorvastatin treatment continued. We measured infarct size, hemodynamics and the plasma levels and the mRNA expression of TNF-alpha and IL-10 in the three groups. We demonstrated that the up-regulation of expression of both TNF-alpha mRNA and IL-10 mRNA was associated the increased plasma levels of TNF-alpha and IL-10 in the ischemic and reperfused myocardium compared with that in the sham group (P<0.01). Atorvastatin treatment prevented ischemia-reperfusion-induced up-regulation of both TNF-alpha and IL-10 mRNA, and improved left ventricular function (P<0.01). Our findings suggested that atorvastatin may attenuate MI/R and better recovery of left ventricle function following ischemia and reperfusion and IL-10 was not directly likely involved in this protective mechanism." @default.
- W2007342138 created "2016-06-24" @default.
- W2007342138 creator A5025317539 @default.
- W2007342138 creator A5032135998 @default.
- W2007342138 creator A5044396095 @default.
- W2007342138 creator A5050707734 @default.
- W2007342138 creator A5066438889 @default.
- W2007342138 creator A5080576001 @default.
- W2007342138 creator A5082912383 @default.
- W2007342138 creator A5089862084 @default.
- W2007342138 date "2009-05-01" @default.
- W2007342138 modified "2023-10-14" @default.
- W2007342138 title "Effect of atorvastatin on expression of IL-10 and TNF-α mRNA in myocardial ischemia–reperfusion injury in rats" @default.
- W2007342138 cites W1835281509 @default.
- W2007342138 cites W1965992445 @default.
- W2007342138 cites W1983893679 @default.
- W2007342138 cites W1986273912 @default.
- W2007342138 cites W1986378496 @default.
- W2007342138 cites W1990255353 @default.
- W2007342138 cites W1991117742 @default.
- W2007342138 cites W2010893626 @default.
- W2007342138 cites W2021685843 @default.
- W2007342138 cites W2032901102 @default.
- W2007342138 cites W2033414209 @default.
- W2007342138 cites W2067322348 @default.
- W2007342138 cites W2069378329 @default.
- W2007342138 cites W2072935797 @default.
- W2007342138 cites W2076990506 @default.
- W2007342138 cites W2095684289 @default.
- W2007342138 cites W2097187941 @default.
- W2007342138 cites W2101333224 @default.
- W2007342138 cites W2106011334 @default.
- W2007342138 cites W2106171330 @default.
- W2007342138 cites W2120265067 @default.
- W2007342138 cites W2120858735 @default.
- W2007342138 cites W2135070269 @default.
- W2007342138 cites W2147159782 @default.
- W2007342138 cites W2154937466 @default.
- W2007342138 cites W2170553367 @default.
- W2007342138 cites W2191654227 @default.
- W2007342138 cites W2419511788 @default.
- W2007342138 cites W41406262 @default.
- W2007342138 doi "https://doi.org/10.1016/j.bbrc.2009.03.019" @default.
- W2007342138 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19275881" @default.
- W2007342138 hasPublicationYear "2009" @default.
- W2007342138 type Work @default.
- W2007342138 sameAs 2007342138 @default.
- W2007342138 citedByCount "25" @default.
- W2007342138 countsByYear W20073421382012 @default.
- W2007342138 countsByYear W20073421382013 @default.
- W2007342138 countsByYear W20073421382014 @default.
- W2007342138 countsByYear W20073421382015 @default.
- W2007342138 countsByYear W20073421382016 @default.
- W2007342138 countsByYear W20073421382017 @default.
- W2007342138 countsByYear W20073421382019 @default.
- W2007342138 countsByYear W20073421382020 @default.
- W2007342138 countsByYear W20073421382022 @default.
- W2007342138 countsByYear W20073421382023 @default.
- W2007342138 crossrefType "journal-article" @default.
- W2007342138 hasAuthorship W2007342138A5025317539 @default.
- W2007342138 hasAuthorship W2007342138A5032135998 @default.
- W2007342138 hasAuthorship W2007342138A5044396095 @default.
- W2007342138 hasAuthorship W2007342138A5050707734 @default.
- W2007342138 hasAuthorship W2007342138A5066438889 @default.
- W2007342138 hasAuthorship W2007342138A5080576001 @default.
- W2007342138 hasAuthorship W2007342138A5082912383 @default.
- W2007342138 hasAuthorship W2007342138A5089862084 @default.
- W2007342138 hasConcept C104317684 @default.
- W2007342138 hasConcept C105580179 @default.
- W2007342138 hasConcept C126322002 @default.
- W2007342138 hasConcept C134018914 @default.
- W2007342138 hasConcept C164705383 @default.
- W2007342138 hasConcept C17991360 @default.
- W2007342138 hasConcept C185592680 @default.
- W2007342138 hasConcept C2777482532 @default.
- W2007342138 hasConcept C2778921608 @default.
- W2007342138 hasConcept C2780114680 @default.
- W2007342138 hasConcept C42219234 @default.
- W2007342138 hasConcept C541997718 @default.
- W2007342138 hasConcept C55493867 @default.
- W2007342138 hasConcept C71924100 @default.
- W2007342138 hasConcept C98274493 @default.
- W2007342138 hasConceptScore W2007342138C104317684 @default.
- W2007342138 hasConceptScore W2007342138C105580179 @default.
- W2007342138 hasConceptScore W2007342138C126322002 @default.
- W2007342138 hasConceptScore W2007342138C134018914 @default.
- W2007342138 hasConceptScore W2007342138C164705383 @default.
- W2007342138 hasConceptScore W2007342138C17991360 @default.
- W2007342138 hasConceptScore W2007342138C185592680 @default.
- W2007342138 hasConceptScore W2007342138C2777482532 @default.
- W2007342138 hasConceptScore W2007342138C2778921608 @default.
- W2007342138 hasConceptScore W2007342138C2780114680 @default.
- W2007342138 hasConceptScore W2007342138C42219234 @default.
- W2007342138 hasConceptScore W2007342138C541997718 @default.
- W2007342138 hasConceptScore W2007342138C55493867 @default.
- W2007342138 hasConceptScore W2007342138C71924100 @default.
- W2007342138 hasConceptScore W2007342138C98274493 @default.
- W2007342138 hasIssue "2" @default.