Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007342246> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2007342246 abstract "Advanced head and neck cancers are one of the most challenging cancers facing the oncologists due to their aggressiveness attributable to the high hypoxic content and the tumour's ability to repopulate during radiotherapy. Alterations of radiotherapy fractionation schedules are possible ways to improve tumour control. Clinical trials have shown that both hyperfractionated radiotherapy (multiple fractions a day, over the same treatment time), and accelerated radiotherapy (higher doses per fraction, six days a week, over 5 weeks or less) are more effective than conventional radiotherapy in the management of head and neck cancer. However, the treatment choice between hyperfractionated and accelerated radiotherapy is still debated, due to very similar results obtained regarding tumour control. Furthermore, while radiotherapy alone has an impact on the short-term prognosis of advanced head and neck cancer, the long-term benefits have been moderate. Cisplatin is a chemotherapeutic agent which combined with conventional radiotherapy has shown to improve patient survival. The present paper employs a Monte Carlo modelling approach in assessing the effect of combined cisplatin-altered fractionation schedule on tumour response. The growth of a head and neck carcinoma has been modelled using probabilistic functions sampled by computer generated random number sequences, maintaining the biological constitution of a tumour. The tumour growth model has been built to simulate the in vivo processes taking place before and after radiotherapy/chemotherapy. The model has shown that adding cisplatin to radiotherapy improves tumour control in both hyperfractionated and accelerated radiotherapy." @default.
- W2007342246 created "2016-06-24" @default.
- W2007342246 creator A5009380500 @default.
- W2007342246 creator A5027460327 @default.
- W2007342246 date "2010-10-01" @default.
- W2007342246 modified "2023-09-26" @default.
- W2007342246 title "Stochastic modelling of the role of cisplatin in altered fractionation schedules for head and neck cancer" @default.
- W2007342246 cites W1576463423 @default.
- W2007342246 cites W1966675362 @default.
- W2007342246 cites W2011447425 @default.
- W2007342246 cites W2013012955 @default.
- W2007342246 cites W2022302560 @default.
- W2007342246 cites W2026097725 @default.
- W2007342246 cites W2056118025 @default.
- W2007342246 cites W2059784012 @default.
- W2007342246 cites W2066334626 @default.
- W2007342246 cites W2075061494 @default.
- W2007342246 cites W2112207507 @default.
- W2007342246 cites W2123551763 @default.
- W2007342246 cites W2150335546 @default.
- W2007342246 cites W2151415400 @default.
- W2007342246 cites W2171524637 @default.
- W2007342246 cites W2618374231 @default.
- W2007342246 cites W3021368244 @default.
- W2007342246 cites W584609198 @default.
- W2007342246 cites W612414919 @default.
- W2007342246 doi "https://doi.org/10.1016/j.ejmp.2009.11.004" @default.
- W2007342246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20034829" @default.
- W2007342246 hasPublicationYear "2010" @default.
- W2007342246 type Work @default.
- W2007342246 sameAs 2007342246 @default.
- W2007342246 citedByCount "2" @default.
- W2007342246 countsByYear W20073422462015 @default.
- W2007342246 countsByYear W20073422462019 @default.
- W2007342246 crossrefType "journal-article" @default.
- W2007342246 hasAuthorship W2007342246A5009380500 @default.
- W2007342246 hasAuthorship W2007342246A5027460327 @default.
- W2007342246 hasConcept C121608353 @default.
- W2007342246 hasConcept C126322002 @default.
- W2007342246 hasConcept C141071460 @default.
- W2007342246 hasConcept C143998085 @default.
- W2007342246 hasConcept C155806632 @default.
- W2007342246 hasConcept C2776530083 @default.
- W2007342246 hasConcept C2776694085 @default.
- W2007342246 hasConcept C2778239845 @default.
- W2007342246 hasConcept C2908786992 @default.
- W2007342246 hasConcept C3018411727 @default.
- W2007342246 hasConcept C509974204 @default.
- W2007342246 hasConcept C71924100 @default.
- W2007342246 hasConceptScore W2007342246C121608353 @default.
- W2007342246 hasConceptScore W2007342246C126322002 @default.
- W2007342246 hasConceptScore W2007342246C141071460 @default.
- W2007342246 hasConceptScore W2007342246C143998085 @default.
- W2007342246 hasConceptScore W2007342246C155806632 @default.
- W2007342246 hasConceptScore W2007342246C2776530083 @default.
- W2007342246 hasConceptScore W2007342246C2776694085 @default.
- W2007342246 hasConceptScore W2007342246C2778239845 @default.
- W2007342246 hasConceptScore W2007342246C2908786992 @default.
- W2007342246 hasConceptScore W2007342246C3018411727 @default.
- W2007342246 hasConceptScore W2007342246C509974204 @default.
- W2007342246 hasConceptScore W2007342246C71924100 @default.
- W2007342246 hasLocation W20073422461 @default.
- W2007342246 hasLocation W20073422462 @default.
- W2007342246 hasOpenAccess W2007342246 @default.
- W2007342246 hasPrimaryLocation W20073422461 @default.
- W2007342246 isParatext "false" @default.
- W2007342246 isRetracted "false" @default.
- W2007342246 magId "2007342246" @default.
- W2007342246 workType "article" @default.