Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007347926> ?p ?o ?g. }
- W2007347926 endingPage "71" @default.
- W2007347926 startingPage "63" @default.
- W2007347926 abstract "This study was performed to examine whether an erythromycin derivative, de(N-methyl)-N-isopropyl-8,9-anhydroerythromycin A 6,9-hemiacetal (EM574) is a motilin receptor agonist in the rabbit gastrointestinal tract. EM574 and porcine motilin induced contractions in segments of isolated rabbit intestine with pEC50 values of 8.26 +/- 0.04 and 8.69 +/- 0.07, respectively, but not in rat or guinea pig preparations. The sensitivity and efficacy of the response to both compounds in rabbits decreased aborally and was insensitive to pretreatment with atropine or tetrodotoxin, but was markedly suppressed under Ca(2+)-free conditions. EM574 and porcine motilin specifically displaced [125I-Tyr23]canine motilin bound to gastric antral smooth muscle homogenates with plC50 values of 8.21 +/- 0.13 and 9.20 +/- 0.11, respectively. The pEC50 value for the contractile response and plC50 value for the receptor binding for motilin, EM574, erythromycin A and three other derivatives correlated well (r = 0.94, P < 0.01). Tissue section autoradiography in the antrum revealed that specific labeled motilin binding sites were localized in the circular muscle layer and myenteric plexus, and could be reduced in the presence of an excess of EM574. These results indicate that EM574 is a potent motilin receptor agonist in the rabbit gastrointestinal tract." @default.
- W2007347926 created "2016-06-24" @default.
- W2007347926 creator A5031484098 @default.
- W2007347926 creator A5040993057 @default.
- W2007347926 creator A5045164227 @default.
- W2007347926 creator A5050372462 @default.
- W2007347926 creator A5055559182 @default.
- W2007347926 creator A5074204610 @default.
- W2007347926 creator A5076500328 @default.
- W2007347926 date "1997-03-01" @default.
- W2007347926 modified "2023-10-18" @default.
- W2007347926 title "EM574, an erythromycin derivative, is a motilin receptor agonist in the rabbit" @default.
- W2007347926 cites W1480500461 @default.
- W2007347926 cites W1501157082 @default.
- W2007347926 cites W1775749144 @default.
- W2007347926 cites W1858298291 @default.
- W2007347926 cites W1893514296 @default.
- W2007347926 cites W1966029265 @default.
- W2007347926 cites W1969983144 @default.
- W2007347926 cites W1973415543 @default.
- W2007347926 cites W1976781959 @default.
- W2007347926 cites W1982353838 @default.
- W2007347926 cites W1983649348 @default.
- W2007347926 cites W1994101924 @default.
- W2007347926 cites W1995417881 @default.
- W2007347926 cites W2009289404 @default.
- W2007347926 cites W2027606442 @default.
- W2007347926 cites W2027614762 @default.
- W2007347926 cites W2032047716 @default.
- W2007347926 cites W2032354013 @default.
- W2007347926 cites W2038341453 @default.
- W2007347926 cites W2042403352 @default.
- W2007347926 cites W2052307412 @default.
- W2007347926 cites W2061250924 @default.
- W2007347926 cites W2080338186 @default.
- W2007347926 cites W2080959674 @default.
- W2007347926 cites W2082524543 @default.
- W2007347926 cites W2084248346 @default.
- W2007347926 cites W2092253259 @default.
- W2007347926 cites W2094618334 @default.
- W2007347926 cites W2136431524 @default.
- W2007347926 cites W2148179192 @default.
- W2007347926 cites W2157662999 @default.
- W2007347926 cites W2159207825 @default.
- W2007347926 cites W2274724535 @default.
- W2007347926 cites W2327122843 @default.
- W2007347926 cites W2413389452 @default.
- W2007347926 cites W75759039 @default.
- W2007347926 doi "https://doi.org/10.1016/s0014-2999(96)00983-1" @default.
- W2007347926 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9088872" @default.
- W2007347926 hasPublicationYear "1997" @default.
- W2007347926 type Work @default.
- W2007347926 sameAs 2007347926 @default.
- W2007347926 citedByCount "15" @default.
- W2007347926 crossrefType "journal-article" @default.
- W2007347926 hasAuthorship W2007347926A5031484098 @default.
- W2007347926 hasAuthorship W2007347926A5040993057 @default.
- W2007347926 hasAuthorship W2007347926A5045164227 @default.
- W2007347926 hasAuthorship W2007347926A5050372462 @default.
- W2007347926 hasAuthorship W2007347926A5055559182 @default.
- W2007347926 hasAuthorship W2007347926A5074204610 @default.
- W2007347926 hasAuthorship W2007347926A5076500328 @default.
- W2007347926 hasConcept C126322002 @default.
- W2007347926 hasConcept C131253125 @default.
- W2007347926 hasConcept C131793682 @default.
- W2007347926 hasConcept C134018914 @default.
- W2007347926 hasConcept C170493617 @default.
- W2007347926 hasConcept C185592680 @default.
- W2007347926 hasConcept C204232928 @default.
- W2007347926 hasConcept C2775859210 @default.
- W2007347926 hasConcept C2776741303 @default.
- W2007347926 hasConcept C2776907353 @default.
- W2007347926 hasConcept C2778815084 @default.
- W2007347926 hasConcept C2778938600 @default.
- W2007347926 hasConcept C2779422922 @default.
- W2007347926 hasConcept C2780206985 @default.
- W2007347926 hasConcept C3017563778 @default.
- W2007347926 hasConcept C501593827 @default.
- W2007347926 hasConcept C55493867 @default.
- W2007347926 hasConcept C71924100 @default.
- W2007347926 hasConcept C86803240 @default.
- W2007347926 hasConceptScore W2007347926C126322002 @default.
- W2007347926 hasConceptScore W2007347926C131253125 @default.
- W2007347926 hasConceptScore W2007347926C131793682 @default.
- W2007347926 hasConceptScore W2007347926C134018914 @default.
- W2007347926 hasConceptScore W2007347926C170493617 @default.
- W2007347926 hasConceptScore W2007347926C185592680 @default.
- W2007347926 hasConceptScore W2007347926C204232928 @default.
- W2007347926 hasConceptScore W2007347926C2775859210 @default.
- W2007347926 hasConceptScore W2007347926C2776741303 @default.
- W2007347926 hasConceptScore W2007347926C2776907353 @default.
- W2007347926 hasConceptScore W2007347926C2778815084 @default.
- W2007347926 hasConceptScore W2007347926C2778938600 @default.
- W2007347926 hasConceptScore W2007347926C2779422922 @default.
- W2007347926 hasConceptScore W2007347926C2780206985 @default.
- W2007347926 hasConceptScore W2007347926C3017563778 @default.
- W2007347926 hasConceptScore W2007347926C501593827 @default.
- W2007347926 hasConceptScore W2007347926C55493867 @default.