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- W2007348274 abstract "The X-chromosomal geneglucose-6-phosphate dehydrogenase(G6pd) is known to be expressed in most cell types of mammalian species. In the mouse, we have detected a novel gene, designatedG6pd-2,encoding a G6PD isoenzyme.G6pd-2does not contain introns and appears to represent a retroposed gene. This gene is uniquely transcribed in postmeiotic spermatogenic cells in which the X-encodedG6pdgene is not transcribed. Expression of theG6pd-2sequence in a bacterial system showed that the encoded product is an active enzyme. Zymogramic analysis demonstrated that recombinant G6PD-2, but not recombinant G6PD-1 (the X-chromosome-encoded G6PD), formed tetramers under reducing conditions. Under the same conditions, G6PD tetramers were also found in extracts of spermatids and spermatozoa, indicating the presence ofG6pd-2-encoded isoenzyme in these cell types.G6pd-2is one of the very few known expressed retroposons encoding a functional protein, and the presence of this gene is probably related to X chromosome inactivation during spermatogenesis." @default.
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- W2007348274 date "1997-05-01" @default.
- W2007348274 modified "2023-10-17" @default.
- W2007348274 title "Testis-Specific Expression of a Functional Retroposon Encoding Glucose-6-phosphate Dehydrogenase in the Mouse" @default.
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- W2007348274 doi "https://doi.org/10.1006/geno.1997.4673" @default.
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