Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007348532> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2007348532 endingPage "20" @default.
- W2007348532 startingPage "19" @default.
- W2007348532 abstract "The vital role played by prolactin during pregnancy and lactation is emphasized by the physiological adaptations that occur in the mother to maintain a prolonged state of hyperprolactinemia. In many species the placenta provides a source of lactogenic hormones in the circulation, ensuring the continued presence of a hormone capable of activating the prolactin receptor throughout pregnancy. In addition, the tuberoinfundibular dopamine neurons, which normally maintain a tonic inhibitory influence over prolactin secretion, show a reduced ability to respond to prolactin during late pregnancy and lactation, allowing high levels of prolactin to be maintained unopposed by a regulatory feedback mechanisms. There is clear evidence that systemic prolactin gains access to the cerebrospinal fluid, from where it can diffuse to numerous brain regions. Prolactin receptors are expressed in several hypothalamic nuclei, including the medial preoptic and arcuate nuclei, and we have observed marked increases in expression of prolactin receptors in these nuclei during lactation. Moreover, a number of hypothalamic nuclei, including the paraventricular, supraoptic and ventromedial nuclei, in which prolactin receptors were not detected in diestrous rats, were found to express significant amounts of prolactin receptor during lactation. These observations have important implications for the variety of documented actions of prolactin on the brain. Prolactin has been reported to influence numerous brain functions, including maternal behavior, feeding and appetite, oxytocin secretion, and ACTH secretion in response to stress. In light of the high circulating levels of prolactin during pregnancy and lactation and the increased expression of prolactin receptors in the hypothalamus, many of these effects of prolactin may be enhanced or exaggerated during lactation. Hence, prolactin may be a key player in the coordination of neuroendocrine and behavioral adaptations of the maternal brain." @default.
- W2007348532 created "2016-06-24" @default.
- W2007348532 creator A5006392874 @default.
- W2007348532 creator A5041408914 @default.
- W2007348532 creator A5056332852 @default.
- W2007348532 creator A5058509350 @default.
- W2007348532 creator A5085917194 @default.
- W2007348532 date "1990-09-01" @default.
- W2007348532 modified "2023-09-24" @default.
- W2007348532 title "Biochemical and autoradiographic identification of prolactin binding sites in the rat hypothalamus" @default.
- W2007348532 cites W1984894677 @default.
- W2007348532 cites W2045166609 @default.
- W2007348532 cites W2064038284 @default.
- W2007348532 cites W2076053312 @default.
- W2007348532 doi "https://doi.org/10.1016/s1043-6618(09)80008-x" @default.
- W2007348532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2097629" @default.
- W2007348532 hasPublicationYear "1990" @default.
- W2007348532 type Work @default.
- W2007348532 sameAs 2007348532 @default.
- W2007348532 citedByCount "5" @default.
- W2007348532 crossrefType "journal-article" @default.
- W2007348532 hasAuthorship W2007348532A5006392874 @default.
- W2007348532 hasAuthorship W2007348532A5041408914 @default.
- W2007348532 hasAuthorship W2007348532A5056332852 @default.
- W2007348532 hasAuthorship W2007348532A5058509350 @default.
- W2007348532 hasAuthorship W2007348532A5085917194 @default.
- W2007348532 hasConcept C126322002 @default.
- W2007348532 hasConcept C134018914 @default.
- W2007348532 hasConcept C170493617 @default.
- W2007348532 hasConcept C2776176026 @default.
- W2007348532 hasConcept C2776659692 @default.
- W2007348532 hasConcept C2777003273 @default.
- W2007348532 hasConcept C2779064019 @default.
- W2007348532 hasConcept C2779234561 @default.
- W2007348532 hasConcept C2781031661 @default.
- W2007348532 hasConcept C54355233 @default.
- W2007348532 hasConcept C54799321 @default.
- W2007348532 hasConcept C71315377 @default.
- W2007348532 hasConcept C71924100 @default.
- W2007348532 hasConcept C86803240 @default.
- W2007348532 hasConceptScore W2007348532C126322002 @default.
- W2007348532 hasConceptScore W2007348532C134018914 @default.
- W2007348532 hasConceptScore W2007348532C170493617 @default.
- W2007348532 hasConceptScore W2007348532C2776176026 @default.
- W2007348532 hasConceptScore W2007348532C2776659692 @default.
- W2007348532 hasConceptScore W2007348532C2777003273 @default.
- W2007348532 hasConceptScore W2007348532C2779064019 @default.
- W2007348532 hasConceptScore W2007348532C2779234561 @default.
- W2007348532 hasConceptScore W2007348532C2781031661 @default.
- W2007348532 hasConceptScore W2007348532C54355233 @default.
- W2007348532 hasConceptScore W2007348532C54799321 @default.
- W2007348532 hasConceptScore W2007348532C71315377 @default.
- W2007348532 hasConceptScore W2007348532C71924100 @default.
- W2007348532 hasConceptScore W2007348532C86803240 @default.
- W2007348532 hasLocation W20073485321 @default.
- W2007348532 hasLocation W20073485322 @default.
- W2007348532 hasOpenAccess W2007348532 @default.
- W2007348532 hasPrimaryLocation W20073485321 @default.
- W2007348532 hasRelatedWork W1967155978 @default.
- W2007348532 hasRelatedWork W1978447652 @default.
- W2007348532 hasRelatedWork W1993773663 @default.
- W2007348532 hasRelatedWork W2016202130 @default.
- W2007348532 hasRelatedWork W2022317917 @default.
- W2007348532 hasRelatedWork W2032920953 @default.
- W2007348532 hasRelatedWork W2044117464 @default.
- W2007348532 hasRelatedWork W2103188824 @default.
- W2007348532 hasRelatedWork W2129625801 @default.
- W2007348532 hasRelatedWork W219544857 @default.
- W2007348532 hasVolume "22" @default.
- W2007348532 isParatext "false" @default.
- W2007348532 isRetracted "false" @default.
- W2007348532 magId "2007348532" @default.
- W2007348532 workType "article" @default.