FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007350025> ?p ?o ?g. }

• W2007350025 endingPage "497" @default.
• W2007350025 startingPage "490" @default.
• W2007350025 abstract "Acid cysteine protease was purified from metacercariae of the mammalian trematode parasite Paragonimus westermani. The purified enzyme had a molecular mass of 27 kDa and was a monomeric polypeptide. The protease had an absolute requirement for a reducing agent for full activity towards fluorescein-isothiocyanate-labeled hemoglobin, and it was active in the acidic pH range, with an optimum pH of 4.0. While acidic proteolysis was insensitive to the aspartic protease inhibitor pepstatin A, activity was significantly inhibited by the cysteine protease inhibitors, leupeptin, chymostatin and L-trans -epoxy-succinyl-L-leucylamido(4-guanidino)-butane. The sensitivity of the enzyme to the inhibitors was similar to that of cathepsins B and L, but the specificity of the protease towards chromogenic substrates was slightly different from that of the cathepsins. The purified enzyme was highly specific for N-substituted peptidyl substrates containing arginine in the P, position and phenylalanine in the P2 position, and the protease extensively degraded human native proteins, such as human serum albumin, immunoglobulins, complement components and also endogenous protease inhibitors. Since the protease hydrolyzes both soluble proteins and components of human defense systems, it may facilitate parasite nutrition and evasion of host defense mechanisms." @default.
• W2007350025 created "2016-06-24" @default.
• W2007350025 creator A5008036225 @default.
• W2007350025 creator A5026331641 @default.
• W2007350025 creator A5039771790 @default.
• W2007350025 creator A5087539429 @default.
• W2007350025 date "1995-10-01" @default.
• W2007350025 modified "2023-09-23" @default.
• W2007350025 title "Purification and Characterization of Acid Cysteine Protease from Metacercariae of the Mammalian Trematode Parasite Paragonimus westermani" @default.
• W2007350025 cites W124741863 @default.
• W2007350025 cites W1484675846 @default.
• W2007350025 cites W1485122127 @default.
• W2007350025 cites W1565286236 @default.
• W2007350025 cites W1642470460 @default.
• W2007350025 cites W1967084877 @default.
• W2007350025 cites W1972219122 @default.
• W2007350025 cites W1979625031 @default.
• W2007350025 cites W1985555260 @default.
• W2007350025 cites W1993710192 @default.
• W2007350025 cites W2002560793 @default.
• W2007350025 cites W2006760529 @default.
• W2007350025 cites W2007600140 @default.
• W2007350025 cites W2024209303 @default.
• W2007350025 cites W2049571313 @default.
• W2007350025 cites W2065402657 @default.
• W2007350025 cites W2073684122 @default.
• W2007350025 cites W2074551937 @default.
• W2007350025 cites W2078346621 @default.
• W2007350025 cites W2100837269 @default.
• W2007350025 cites W2110270062 @default.
• W2007350025 cites W2128635872 @default.
• W2007350025 cites W2162280157 @default.
• W2007350025 cites W2314107301 @default.
• W2007350025 cites W2316610829 @default.
• W2007350025 cites W2322821994 @default.
• W2007350025 cites W2323243423 @default.
• W2007350025 cites W2328813281 @default.
• W2007350025 cites W2344863420 @default.
• W2007350025 cites W4242257013 @default.
• W2007350025 cites W4242400292 @default.
• W2007350025 doi "https://doi.org/10.1111/j.1432-1033.1995.490_2.x" @default.
• W2007350025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7588793" @default.
• W2007350025 hasPublicationYear "1995" @default.
• W2007350025 type Work @default.
• W2007350025 sameAs 2007350025 @default.
• W2007350025 citedByCount "22" @default.
• W2007350025 countsByYear W20073500252013 @default.
• W2007350025 countsByYear W20073500252016 @default.
• W2007350025 countsByYear W20073500252020 @default.
• W2007350025 countsByYear W20073500252021 @default.
• W2007350025 crossrefType "journal-article" @default.
• W2007350025 hasAuthorship W2007350025A5008036225 @default.
• W2007350025 hasAuthorship W2007350025A5026331641 @default.
• W2007350025 hasAuthorship W2007350025A5039771790 @default.
• W2007350025 hasAuthorship W2007350025A5087539429 @default.
• W2007350025 hasBestOaLocation W20073500251 @default.
• W2007350025 hasConcept C153911025 @default.
• W2007350025 hasConcept C165901193 @default.
• W2007350025 hasConcept C181199279 @default.
• W2007350025 hasConcept C185592680 @default.
• W2007350025 hasConcept C2775883766 @default.
• W2007350025 hasConcept C2776350231 @default.
• W2007350025 hasConcept C2776714187 @default.
• W2007350025 hasConcept C2777283782 @default.
• W2007350025 hasConcept C2778083953 @default.
• W2007350025 hasConcept C2779201268 @default.
• W2007350025 hasConcept C2779613767 @default.
• W2007350025 hasConcept C55493867 @default.
• W2007350025 hasConcept C86803240 @default.
• W2007350025 hasConcept C90856448 @default.
• W2007350025 hasConceptScore W2007350025C153911025 @default.
• W2007350025 hasConceptScore W2007350025C165901193 @default.
• W2007350025 hasConceptScore W2007350025C181199279 @default.
• W2007350025 hasConceptScore W2007350025C185592680 @default.
• W2007350025 hasConceptScore W2007350025C2775883766 @default.
• W2007350025 hasConceptScore W2007350025C2776350231 @default.
• W2007350025 hasConceptScore W2007350025C2776714187 @default.
• W2007350025 hasConceptScore W2007350025C2777283782 @default.
• W2007350025 hasConceptScore W2007350025C2778083953 @default.
• W2007350025 hasConceptScore W2007350025C2779201268 @default.
• W2007350025 hasConceptScore W2007350025C2779613767 @default.
• W2007350025 hasConceptScore W2007350025C55493867 @default.
• W2007350025 hasConceptScore W2007350025C86803240 @default.
• W2007350025 hasConceptScore W2007350025C90856448 @default.
• W2007350025 hasIssue "2" @default.
• W2007350025 hasLocation W20073500251 @default.
• W2007350025 hasLocation W20073500252 @default.
• W2007350025 hasOpenAccess W2007350025 @default.
• W2007350025 hasPrimaryLocation W20073500251 @default.
• W2007350025 hasRelatedWork W1533692222 @default.
• W2007350025 hasRelatedWork W1963743288 @default.
• W2007350025 hasRelatedWork W1970106485 @default.
• W2007350025 hasRelatedWork W1997024873 @default.
• W2007350025 hasRelatedWork W2007350025 @default.
• W2007350025 hasRelatedWork W2033738173 @default.
• W2007350025 hasRelatedWork W2040341722 @default.
• W2007350025 hasRelatedWork W2063249076 @default.
• W2007350025 hasRelatedWork W2334677915 @default.

• next