Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007350059> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2007350059 endingPage "3894" @default.
- W2007350059 startingPage "3883" @default.
- W2007350059 abstract "We present the solution structure of the nonpalindromic 16 bp DNA 5‘d(CTGCTCACTTTCCAGG)3‘. 5‘d(CCTGGAAAGTGAGCAG)3‘ containing a mutated κB site for which the mutation of a highly conserved GGG tract of the native κB HIV-1 site to CTC abolishes NF-κB binding. 1H and 31P NMR spectroscopies have been used together with molecular modeling to determine the fine structure of the duplex. NMR data show evidence for a BI−BII equilibrium of the CpA·TpG steps at the 3‘-end of the oligomer. Models for the extreme conformations reached by the mutated duplex (denoted 16M) are proposed in agreement with the NMR data. Since the distribution of BII sites is changed in the mutated duplex compared to that of the native duplex (denoted 16N), large differences are induced in the intrinsic structural properties of both duplexes. In particular, in BII structures, 16M shows a kink located at the 3‘-end of the duplex, and in contrast, 16N exhibits an intrinsic global curvature toward the major groove. Whereas 16N can reach a conformation very favorable for the interaction with NF-κB, 16M cannot mimic such a conformation and, moreover, its deeper and narrower major groove could hinder the DNA−protein interactions." @default.
- W2007350059 created "2016-06-24" @default.
- W2007350059 creator A5046340967 @default.
- W2007350059 creator A5072693404 @default.
- W2007350059 creator A5089438108 @default.
- W2007350059 date "1999-03-01" @default.
- W2007350059 modified "2023-09-25" @default.
- W2007350059 title "NF-κB Binding Mechanism: A Nuclear Magnetic Resonance and Modeling Study of a GGG → CTC Mutation" @default.
- W2007350059 cites W1508413828 @default.
- W2007350059 cites W1539032650 @default.
- W2007350059 cites W1963318377 @default.
- W2007350059 cites W1972459558 @default.
- W2007350059 cites W1975358529 @default.
- W2007350059 cites W1983177130 @default.
- W2007350059 cites W1994448943 @default.
- W2007350059 cites W1997789431 @default.
- W2007350059 cites W2050843661 @default.
- W2007350059 cites W2051923979 @default.
- W2007350059 cites W2054243991 @default.
- W2007350059 cites W2059311617 @default.
- W2007350059 cites W2065426928 @default.
- W2007350059 cites W2070702404 @default.
- W2007350059 cites W2085848314 @default.
- W2007350059 cites W2107104314 @default.
- W2007350059 cites W2122199548 @default.
- W2007350059 cites W2149272138 @default.
- W2007350059 cites W2949250147 @default.
- W2007350059 cites W2951392003 @default.
- W2007350059 doi "https://doi.org/10.1021/bi982402d" @default.
- W2007350059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10194299" @default.
- W2007350059 hasPublicationYear "1999" @default.
- W2007350059 type Work @default.
- W2007350059 sameAs 2007350059 @default.
- W2007350059 citedByCount "32" @default.
- W2007350059 countsByYear W20073500592012 @default.
- W2007350059 countsByYear W20073500592013 @default.
- W2007350059 countsByYear W20073500592015 @default.
- W2007350059 countsByYear W20073500592016 @default.
- W2007350059 countsByYear W20073500592017 @default.
- W2007350059 countsByYear W20073500592019 @default.
- W2007350059 countsByYear W20073500592022 @default.
- W2007350059 crossrefType "journal-article" @default.
- W2007350059 hasAuthorship W2007350059A5046340967 @default.
- W2007350059 hasAuthorship W2007350059A5072693404 @default.
- W2007350059 hasAuthorship W2007350059A5089438108 @default.
- W2007350059 hasConcept C112887158 @default.
- W2007350059 hasConcept C12554922 @default.
- W2007350059 hasConcept C178790620 @default.
- W2007350059 hasConcept C185592680 @default.
- W2007350059 hasConcept C2780642029 @default.
- W2007350059 hasConcept C32909587 @default.
- W2007350059 hasConcept C552990157 @default.
- W2007350059 hasConcept C55493867 @default.
- W2007350059 hasConcept C66974803 @default.
- W2007350059 hasConcept C71240020 @default.
- W2007350059 hasConcept C8010536 @default.
- W2007350059 hasConcept C86803240 @default.
- W2007350059 hasConcept C99611785 @default.
- W2007350059 hasConceptScore W2007350059C112887158 @default.
- W2007350059 hasConceptScore W2007350059C12554922 @default.
- W2007350059 hasConceptScore W2007350059C178790620 @default.
- W2007350059 hasConceptScore W2007350059C185592680 @default.
- W2007350059 hasConceptScore W2007350059C2780642029 @default.
- W2007350059 hasConceptScore W2007350059C32909587 @default.
- W2007350059 hasConceptScore W2007350059C552990157 @default.
- W2007350059 hasConceptScore W2007350059C55493867 @default.
- W2007350059 hasConceptScore W2007350059C66974803 @default.
- W2007350059 hasConceptScore W2007350059C71240020 @default.
- W2007350059 hasConceptScore W2007350059C8010536 @default.
- W2007350059 hasConceptScore W2007350059C86803240 @default.
- W2007350059 hasConceptScore W2007350059C99611785 @default.
- W2007350059 hasIssue "13" @default.
- W2007350059 hasLocation W20073500591 @default.
- W2007350059 hasLocation W20073500592 @default.
- W2007350059 hasOpenAccess W2007350059 @default.
- W2007350059 hasPrimaryLocation W20073500591 @default.
- W2007350059 hasRelatedWork W1981578189 @default.
- W2007350059 hasRelatedWork W1995372961 @default.
- W2007350059 hasRelatedWork W2022199482 @default.
- W2007350059 hasRelatedWork W2033018937 @default.
- W2007350059 hasRelatedWork W2054176944 @default.
- W2007350059 hasRelatedWork W2093137798 @default.
- W2007350059 hasRelatedWork W2145381472 @default.
- W2007350059 hasRelatedWork W2411278664 @default.
- W2007350059 hasRelatedWork W4293372989 @default.
- W2007350059 hasRelatedWork W2316639732 @default.
- W2007350059 hasVolume "38" @default.
- W2007350059 isParatext "false" @default.
- W2007350059 isRetracted "false" @default.
- W2007350059 magId "2007350059" @default.
- W2007350059 workType "article" @default.