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• W2007351098 abstract "We have evaluated the relationship between MHC class-I, c-myc and c-fos proto-oncogene expression in several clones of a methylcholanthrene-induced fibrosarcoma (GR9) which originated in a BALB/c mouse. These clones represent a heterogeneous population and differ markedly with regard to H-2 class-I cell-surface expression, local tumor growth, NK sensitivity and metastatic potential. In the present study we show that cell-surface expression of MHC class-I antigens correlates inversely with levels of c-myc mRNA transcripts, On the other hand, mRNA levels of c-fos are correlated directly with the amount of mRNA of MHC class I. Treatment of the B9 clone with gamma interferon increased mRNA transcription and surface expression of H-2 class-I antigens, while c-myc transcription was simultaneously down-regulated. In contrast, c-fos mRNA levels remained unaltered." @default.
• W2007351098 created "2016-06-24" @default.
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• W2007351098 date "1991-12-01" @default.
• W2007351098 modified "2023-10-16" @default.
• W2007351098 title "Differential mRNA levels of c-myc, c-fos and MHC class I in several clones of a murine fibrosarcoma" @default.
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• W2007351098 doi "https://doi.org/10.1002/ijc.2910490618" @default.
• W2007351098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1959995" @default.
• W2007351098 hasPublicationYear "1991" @default.
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