FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007351276> ?p ?o ?g. }

• W2007351276 abstract "Abstract Background Epimedii herba is one of the most frequently used herbs in formulas that are prescribed for the treatment of osteoporosis in China and its main constituent is Epimedium pubescen flavonoid (EPF). However, it is unclear whether EPF during chronic exposure to cigarette smoke may have a protective influence on the skeleton. The present study investigated the effect of EPF on bone mineral status and bone turnover in a rat model of human relatively high exposure to cigarette smoke. Methods Fifty male Wistar rats were randomized into five groups: controls, passive smoking groups and passive smoking rats administered EPF at three dosage levels (75, 150 or 300 mg/kg/day) in drinking water for 4 months. A rat model of passive smoking was prepared by breeding male rats in a cigarette-smoking box. Bone mineral content (BMC), bone mineral density (BMD), bone turnover markers, bone histomorphometric parameters and biomechanical properties were examined. Results Smoke exposure decreased BMC and BMD, increased bone turnover (inhibited bone formation and stimulated its resorption), affected bone histomorphometry (increased trabecular separation and osteoclast surface per bone surface; decreased trabecular bone volume, trabecular thickness, trabecular number, cortical thickness, bone formation rate and osteoblast surface per bone surface), and reduced mechanical properties. EPF supplementation during cigarette smoke exposure prevented smoke-induced changes in bone mineral status and bone turnover. Conclusion The results suggest that EPF can prevent the adverse effects of smoke exposure on bone by stimulating bone formation and inhibiting bone turnover and bone resorption." @default.
• W2007351276 created "2016-06-24" @default.
• W2007351276 creator A5007264357 @default.
• W2007351276 creator A5012363045 @default.
• W2007351276 creator A5024181294 @default.
• W2007351276 creator A5031293218 @default.
• W2007351276 creator A5039458269 @default.
• W2007351276 creator A5041571735 @default.
• W2007351276 creator A5044007108 @default.
• W2007351276 creator A5045007670 @default.
• W2007351276 creator A5049380870 @default.
• W2007351276 creator A5063237870 @default.
• W2007351276 creator A5065617923 @default.
• W2007351276 creator A5076993036 @default.
• W2007351276 creator A5082193621 @default.
• W2007351276 creator A5083440388 @default.
• W2007351276 creator A5086282793 @default.
• W2007351276 date "2012-06-19" @default.
• W2007351276 modified "2023-10-14" @default.
• W2007351276 title "Effect of epimedium pubescen flavonoid on bone mineral status and bone turnover in male rats chronically exposed to cigarette smoke" @default.
• W2007351276 cites W1516172865 @default.
• W2007351276 cites W1740831120 @default.
• W2007351276 cites W1970547718 @default.
• W2007351276 cites W1984235103 @default.
• W2007351276 cites W1987430079 @default.
• W2007351276 cites W1997579601 @default.
• W2007351276 cites W2001933894 @default.
• W2007351276 cites W2002685309 @default.
• W2007351276 cites W2010781233 @default.
• W2007351276 cites W2013380914 @default.
• W2007351276 cites W2013581701 @default.
• W2007351276 cites W2016475494 @default.
• W2007351276 cites W2016487780 @default.
• W2007351276 cites W2017684991 @default.
• W2007351276 cites W2019022588 @default.
• W2007351276 cites W2020851794 @default.
• W2007351276 cites W2024054879 @default.
• W2007351276 cites W2029499588 @default.
• W2007351276 cites W2037701513 @default.
• W2007351276 cites W2040073227 @default.
• W2007351276 cites W2041598849 @default.
• W2007351276 cites W2055421159 @default.
• W2007351276 cites W2056427474 @default.
• W2007351276 cites W2069668213 @default.
• W2007351276 cites W2072778799 @default.
• W2007351276 cites W2077626314 @default.
• W2007351276 cites W2077817309 @default.
• W2007351276 cites W2082200673 @default.
• W2007351276 cites W2086668466 @default.
• W2007351276 cites W2087378917 @default.
• W2007351276 cites W2087872570 @default.
• W2007351276 cites W2091199400 @default.
• W2007351276 cites W2094222385 @default.
• W2007351276 cites W2097824004 @default.
• W2007351276 cites W2123820466 @default.
• W2007351276 cites W2125900617 @default.
• W2007351276 cites W2129055117 @default.
• W2007351276 cites W2135566244 @default.
• W2007351276 cites W2139216037 @default.
• W2007351276 cites W2155769670 @default.
• W2007351276 cites W2167686799 @default.
• W2007351276 doi "https://doi.org/10.1186/1471-2474-13-105" @default.
• W2007351276 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3480917" @default.
• W2007351276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22713117" @default.
• W2007351276 hasPublicationYear "2012" @default.
• W2007351276 type Work @default.
• W2007351276 sameAs 2007351276 @default.
• W2007351276 citedByCount "16" @default.
• W2007351276 countsByYear W20073512762014 @default.
• W2007351276 countsByYear W20073512762015 @default.
• W2007351276 countsByYear W20073512762016 @default.
• W2007351276 countsByYear W20073512762017 @default.
• W2007351276 countsByYear W20073512762018 @default.
• W2007351276 countsByYear W20073512762019 @default.
• W2007351276 countsByYear W20073512762020 @default.
• W2007351276 countsByYear W20073512762023 @default.
• W2007351276 crossrefType "journal-article" @default.
• W2007351276 hasAuthorship W2007351276A5007264357 @default.
• W2007351276 hasAuthorship W2007351276A5012363045 @default.
• W2007351276 hasAuthorship W2007351276A5024181294 @default.
• W2007351276 hasAuthorship W2007351276A5031293218 @default.
• W2007351276 hasAuthorship W2007351276A5039458269 @default.
• W2007351276 hasAuthorship W2007351276A5041571735 @default.
• W2007351276 hasAuthorship W2007351276A5044007108 @default.
• W2007351276 hasAuthorship W2007351276A5045007670 @default.
• W2007351276 hasAuthorship W2007351276A5049380870 @default.
• W2007351276 hasAuthorship W2007351276A5063237870 @default.
• W2007351276 hasAuthorship W2007351276A5065617923 @default.
• W2007351276 hasAuthorship W2007351276A5076993036 @default.
• W2007351276 hasAuthorship W2007351276A5082193621 @default.
• W2007351276 hasAuthorship W2007351276A5083440388 @default.
• W2007351276 hasAuthorship W2007351276A5086282793 @default.
• W2007351276 hasBestOaLocation W20073512761 @default.
• W2007351276 hasConcept C126322002 @default.
• W2007351276 hasConcept C134018914 @default.
• W2007351276 hasConcept C142724271 @default.
• W2007351276 hasConcept C146562846 @default.
• W2007351276 hasConcept C170033053 @default.
• W2007351276 hasConcept C170493617 @default.
• W2007351276 hasConcept C185592680 @default.

• next