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• W2007352784 abstract "Background. CD4+CD25+ regulatory T (Treg) cells are essential for the induction and maintenance of immunologic self-tolerance as well as transplant tolerance. The effects of cyclosporin A (CsA), a widely used immunosuppressive agent, on CD4+CD25+Treg cells in mice were investigated. Methods. Balb/c mice were injected with CsA or control solution for one month. The levels, phenotype, and function of CD4+CD25+Treg cells in these mice were then assayed. Results. The percentages and total cell numbers of CD4+CD25+Treg cells in the peripheral blood and spleen were significantly reduced after the treatment with CsA. The total numbers of CD4+CD25+Treg cells in the thymus of CsA-treated mice were markedly reduced as compared to the control mice. However, the percentage of CD4+CD25+Treg cells in the thymus of CsA-treated mice was markedly enhanced. More CD4+CD25+Treg cells expressing high levels of CD44 and CD45RB, and less CD4+CD25+Treg cells expressing CD62L were observed in CsA-treated mice, compared with the control mice. CD4+CD25+Treg cells expressed slightly lower levels of Foxp3 in CsA-treated mice. Furthermore, CsA markedly impaired the immunosuppressive function of CD4+CD25+Treg cells. Conclusions. CsA significantly impaired the development and function of CD4+CD25+Treg cells. The present studies suggest that CsA may block the potential induction of immune tolerance and increase the susceptibility to develop autoimmune diseases while preventing graft rejection." @default.
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• W2007352784 date "2006-12-15" @default.
• W2007352784 modified "2023-10-16" @default.
• W2007352784 title "A Potential Side Effect of Cyclosporin A: Inhibition of CD4+CD25+ Regulatory T Cells in Mice" @default.
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• W2007352784 doi "https://doi.org/10.1097/01.tp.0000246312.89689.17" @default.
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