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- W2007353628 abstract "Cartilage generation and degradation are regulated by miRNAs. Our previous study has shown altered expression of miR-193b in chondrogenic human adipose-derived mesenchymal stem cells (hADSCs). In the current study, we investigated the role of miR-193b in chondrogenesis and cartilage degradation. Luciferase reporter assays showed that miR-193b targeted seed sequences of the TGFB2 and TGFBR3 3′-UTRs. MiR-193b suppressed the expression of early chondrogenic markers in chondrogenic ATDC5 cells, and TNF-alpha expression in IL-1b-induced PMCs. In conclusion, MiR-193b may inhibit early chondrogenesis by targeting TGFB2 and TGFBR3, and may regulate inflammation by repressing TNF-alpha expression in inflamed chondrocytes." @default.
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- W2007353628 date "2015-02-26" @default.
- W2007353628 modified "2023-09-27" @default.
- W2007353628 title "MiR-193b regulates early chondrogenesis by inhibiting the TGF-beta2 signaling pathway" @default.
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- W2007353628 doi "https://doi.org/10.1016/j.febslet.2015.02.017" @default.
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