Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007356773> ?p ?o ?g. }
- W2007356773 endingPage "1255" @default.
- W2007356773 startingPage "1245" @default.
- W2007356773 abstract "Single microelectrode voltage-clamp recordings were made from submucous neurons of the guinea-pig caecum. The slow excitatory postsynaptic current was compared with the currents induced by neurokinin A and substance P. The current induced by neurokinin A (100-300 nM) was associated with a decreased membrane conductance and reversed in polarity between -90 and -100 mV. The neurokinin A current was reduced by Co2+ (1-2 mM), but was not affected by Cs+ (1-2 mM), Ba2+ (10-100 microM) or low Cl- (20-40 mM) solutions. In about 80% of the neurons, the current induced by substance P (100-300 nM) was associated with a decreased membrane conductance and did not reverse with hyperpolarization of the membrane potential up to -130 mV. The current was reduced by Co2+ (1-2 mM) and augmented by low Cl- (20-40 mM) solutions, but was not affected by Cs+ (1-2 mM) or Ba2+ (10-100 microM)-containing solutions. In about 20% of the neurons, the substance P current reversed in polarity between -100 and -120 mV. The slow excitatory postsynaptic current elicited by repetitive nerve stimulation (10-40 Hz, three to five pulses) was accompanied by a decreased membrane conductance, and reversed in polarity between -90 and -100 mV. The slow excitatory postsynaptic current was abolished by Co2+ (1-2 mM) or low Na+ (12 mM) solutions, but was not affected by Cs+ (1-2 mM), Ba2+ (10-100 microM) or low Cl- (20-40 mM) solutions. In such neurons, the neurokinin A current was reversed at approximately the same potential at which the slow excitatory postsynaptic current was reversed, while the substance P current was not reversed even by much stronger hyperpolarizations. It was concluded that the neurokinin A current was mainly due to depression of potassium conductances, while the substance P current resulted from both increased anion conductance and decreased potassium conductances. The conductance change underlying the slow excitatory postsynaptic current is similar to that caused by neurokinin A." @default.
- W2007356773 created "2016-06-24" @default.
- W2007356773 creator A5006129705 @default.
- W2007356773 creator A5085515114 @default.
- W2007356773 date "1994-10-01" @default.
- W2007356773 modified "2023-10-18" @default.
- W2007356773 title "Neurokinin a mimics the slow excitatory postsynaptic current in submucous plexus neurons of the guinea-pig caecum" @default.
- W2007356773 cites W1205758257 @default.
- W2007356773 cites W1965123670 @default.
- W2007356773 cites W1968138649 @default.
- W2007356773 cites W1972025410 @default.
- W2007356773 cites W1975605935 @default.
- W2007356773 cites W1980787446 @default.
- W2007356773 cites W1982006018 @default.
- W2007356773 cites W1982835040 @default.
- W2007356773 cites W1984602119 @default.
- W2007356773 cites W1992154684 @default.
- W2007356773 cites W1996196738 @default.
- W2007356773 cites W2005291443 @default.
- W2007356773 cites W2021625741 @default.
- W2007356773 cites W2022540525 @default.
- W2007356773 cites W2028716811 @default.
- W2007356773 cites W2040302170 @default.
- W2007356773 cites W2044603573 @default.
- W2007356773 cites W2051403450 @default.
- W2007356773 cites W2060218468 @default.
- W2007356773 cites W2080089728 @default.
- W2007356773 cites W2080786780 @default.
- W2007356773 cites W2083101879 @default.
- W2007356773 cites W2087544266 @default.
- W2007356773 cites W2131135097 @default.
- W2007356773 cites W2152652082 @default.
- W2007356773 cites W2152653893 @default.
- W2007356773 cites W2321590196 @default.
- W2007356773 cites W2409886488 @default.
- W2007356773 cites W2030760311 @default.
- W2007356773 doi "https://doi.org/10.1016/0306-4522(94)90356-5" @default.
- W2007356773 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7531303" @default.
- W2007356773 hasPublicationYear "1994" @default.
- W2007356773 type Work @default.
- W2007356773 sameAs 2007356773 @default.
- W2007356773 citedByCount "6" @default.
- W2007356773 crossrefType "journal-article" @default.
- W2007356773 hasAuthorship W2007356773A5006129705 @default.
- W2007356773 hasAuthorship W2007356773A5085515114 @default.
- W2007356773 hasConcept C100837961 @default.
- W2007356773 hasConcept C112592302 @default.
- W2007356773 hasConcept C118303440 @default.
- W2007356773 hasConcept C12554922 @default.
- W2007356773 hasConcept C126322002 @default.
- W2007356773 hasConcept C131453863 @default.
- W2007356773 hasConcept C134018914 @default.
- W2007356773 hasConcept C147944092 @default.
- W2007356773 hasConcept C169760540 @default.
- W2007356773 hasConcept C170493617 @default.
- W2007356773 hasConcept C17077164 @default.
- W2007356773 hasConcept C181911157 @default.
- W2007356773 hasConcept C185263204 @default.
- W2007356773 hasConcept C185592680 @default.
- W2007356773 hasConcept C197341189 @default.
- W2007356773 hasConcept C2776533618 @default.
- W2007356773 hasConcept C2777056410 @default.
- W2007356773 hasConcept C2778071365 @default.
- W2007356773 hasConcept C2910581834 @default.
- W2007356773 hasConcept C55493867 @default.
- W2007356773 hasConcept C66974803 @default.
- W2007356773 hasConcept C71240020 @default.
- W2007356773 hasConcept C71924100 @default.
- W2007356773 hasConcept C86803240 @default.
- W2007356773 hasConceptScore W2007356773C100837961 @default.
- W2007356773 hasConceptScore W2007356773C112592302 @default.
- W2007356773 hasConceptScore W2007356773C118303440 @default.
- W2007356773 hasConceptScore W2007356773C12554922 @default.
- W2007356773 hasConceptScore W2007356773C126322002 @default.
- W2007356773 hasConceptScore W2007356773C131453863 @default.
- W2007356773 hasConceptScore W2007356773C134018914 @default.
- W2007356773 hasConceptScore W2007356773C147944092 @default.
- W2007356773 hasConceptScore W2007356773C169760540 @default.
- W2007356773 hasConceptScore W2007356773C170493617 @default.
- W2007356773 hasConceptScore W2007356773C17077164 @default.
- W2007356773 hasConceptScore W2007356773C181911157 @default.
- W2007356773 hasConceptScore W2007356773C185263204 @default.
- W2007356773 hasConceptScore W2007356773C185592680 @default.
- W2007356773 hasConceptScore W2007356773C197341189 @default.
- W2007356773 hasConceptScore W2007356773C2776533618 @default.
- W2007356773 hasConceptScore W2007356773C2777056410 @default.
- W2007356773 hasConceptScore W2007356773C2778071365 @default.
- W2007356773 hasConceptScore W2007356773C2910581834 @default.
- W2007356773 hasConceptScore W2007356773C55493867 @default.
- W2007356773 hasConceptScore W2007356773C66974803 @default.
- W2007356773 hasConceptScore W2007356773C71240020 @default.
- W2007356773 hasConceptScore W2007356773C71924100 @default.
- W2007356773 hasConceptScore W2007356773C86803240 @default.
- W2007356773 hasIssue "4" @default.
- W2007356773 hasLocation W20073567731 @default.
- W2007356773 hasLocation W20073567732 @default.
- W2007356773 hasOpenAccess W2007356773 @default.
- W2007356773 hasPrimaryLocation W20073567731 @default.