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- W2007357402 abstract "cancer cells. Finally, we determined the SPON2 mRNA expression in human colorectal tumors by qRT-PCR (n = 60, stages I to III). Results: We verified that the SPON2 expression was increased at the mRNA and protein level in MACC1 expressing SW480 cells compared to parental cells. Moreover, when we reduced the high endogenous MACC1 expression in SW620 cells the SPON2 expression was also decreased in these cells. Furthermore, we demonstrated that MACC1 bound to the promoter region of SPON2. SW480 cells with a high SPON2 expression had a higher migratory, invasive and proliferative ability compared to SW480 control cells. In contrast, a decrease of the high endogenous SPON2 expression in SW620 cells resulted in a lower migratory, invasive and proliferative potential. Finally, the SPON2 expression in metachronously metastasizing colorectal tumors was significantly higher than in tumors without metachronous metastasis. Conclusion: Taken together, we identified the gene SPON2 as new transcriptional target gene of MACC1 and we indicate that it might contribute to the metastatic process in colorectal cancer." @default.
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- W2007357402 date "2012-11-01" @default.
- W2007357402 modified "2023-09-26" @default.
- W2007357402 title "212 Cadherin-catenin Protein Expression Profile in Ovarian Neoplasms" @default.
- W2007357402 doi "https://doi.org/10.1016/s0959-8049(12)72010-5" @default.
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