FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007358788> ?p ?o ?g. }

• W2007358788 endingPage "658" @default.
• W2007358788 startingPage "653" @default.
• W2007358788 abstract "1. Acetycholine-mediated relaxations in phenylephrine-contracted aortas, femoral and mesenteric resistance arteries were studied in vessels from endothelial nitric oxide synthase knock-out (eNOS -/-) and the corresponding wild-type strain (eNOS +/+) C57BL6/SV19 mice. 2. Aortas from eNOS (+/+) mice relaxed to acetylcholine in an endothelium-dependent NG-nitro-L-arginine (L-NOARG) sensitive manner. Aortas from eNOS (-/-) mice did not relax to acetylcholine but demonstrated enhanced sensitivity to both authentic NO and sodium nitroprusside. 3. Relaxation to acetylcholine in femoral arteries was partially inhibited by L-NOARG in vessels from eNOS (+/+) mice, but relaxation in eNOS (-/-) mice was insensitive to a combination of L-NOARG and indomethacin and the guanylyl cyclase inhibitor 1H-[1,2, 4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ). The L-NOARG/ODQ/indomethacin-insensitive relaxation to acetylcholine in femoral arteries was inhibited in the presence of elevated (30 mM) extracellular KCl. 4. In mesenteric resistance vessels from eNOS (+/+) mice, the acetylcholine-mediated relaxation response was completely inhibited by a combination of indomethacin and L-NOARG or by 30 mM KCl alone. In contrast, in mesenteric arteries from eNOS (-/-) mice, the acetylcholine-relaxation response was insensitive to a combination of L-NOARG and indomethacin, but was inhibited in the presence of 30 mM KCl. 5. These data indicate arteries from eNOS (-/-) mice demonstrate a supersensitivity to exogenous NO, and that acetylcholine-induced vasorelaxation of femoral and mesenteric vessels from eNOS (-/-) mice is mediated by an endothelium-derived factor that has properties of an EDHF but is neither NO nor prostacyclin. Furthermore, in mesenteric vessels, there is an upregulation of the role of EDHF in the absence of NO." @default.
• W2007358788 created "2016-06-24" @default.
• W2007358788 creator A5002294811 @default.
• W2007358788 creator A5018971716 @default.
• W2007358788 creator A5073181252 @default.
• W2007358788 creator A5084792115 @default.
• W2007358788 creator A5090404833 @default.
• W2007358788 date "1999-10-01" @default.
• W2007358788 modified "2023-10-14" @default.
• W2007358788 title "Acetylcholine-induced relaxation of peripheral arteries isolated from mice lacking endothelial nitric oxide synthase" @default.
• W2007358788 cites W1546802604 @default.
• W2007358788 cites W1878567514 @default.
• W2007358788 cites W1965554487 @default.
• W2007358788 cites W1966358430 @default.
• W2007358788 cites W1970445852 @default.
• W2007358788 cites W1987059708 @default.
• W2007358788 cites W1993783817 @default.
• W2007358788 cites W2011099732 @default.
• W2007358788 cites W2038258665 @default.
• W2007358788 cites W2048177797 @default.
• W2007358788 cites W2063503589 @default.
• W2007358788 cites W2076783344 @default.
• W2007358788 cites W2091193879 @default.
• W2007358788 cites W2091344741 @default.
• W2007358788 cites W2091499945 @default.
• W2007358788 cites W2094797078 @default.
• W2007358788 cites W2095398301 @default.
• W2007358788 cites W2144486173 @default.
• W2007358788 cites W2160193184 @default.
• W2007358788 cites W2208923264 @default.
• W2007358788 cites W2403669450 @default.
• W2007358788 doi "https://doi.org/10.1038/sj.bjp.0702858" @default.
• W2007358788 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1571697" @default.
• W2007358788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10516645" @default.
• W2007358788 hasPublicationYear "1999" @default.
• W2007358788 type Work @default.
• W2007358788 sameAs 2007358788 @default.
• W2007358788 citedByCount "121" @default.
• W2007358788 countsByYear W20073587882012 @default.
• W2007358788 countsByYear W20073587882013 @default.
• W2007358788 countsByYear W20073587882014 @default.
• W2007358788 countsByYear W20073587882015 @default.
• W2007358788 countsByYear W20073587882016 @default.
• W2007358788 countsByYear W20073587882017 @default.
• W2007358788 countsByYear W20073587882018 @default.
• W2007358788 countsByYear W20073587882019 @default.
• W2007358788 countsByYear W20073587882020 @default.
• W2007358788 countsByYear W20073587882021 @default.
• W2007358788 countsByYear W20073587882022 @default.
• W2007358788 crossrefType "journal-article" @default.
• W2007358788 hasAuthorship W2007358788A5002294811 @default.
• W2007358788 hasAuthorship W2007358788A5018971716 @default.
• W2007358788 hasAuthorship W2007358788A5073181252 @default.
• W2007358788 hasAuthorship W2007358788A5084792115 @default.
• W2007358788 hasAuthorship W2007358788A5090404833 @default.
• W2007358788 hasBestOaLocation W20073587881 @default.
• W2007358788 hasConcept C120770815 @default.
• W2007358788 hasConcept C126322002 @default.
• W2007358788 hasConcept C134018914 @default.
• W2007358788 hasConcept C173803235 @default.
• W2007358788 hasConcept C185592680 @default.
• W2007358788 hasConcept C2775910092 @default.
• W2007358788 hasConcept C2776820930 @default.
• W2007358788 hasConcept C2776992346 @default.
• W2007358788 hasConcept C2777622882 @default.
• W2007358788 hasConcept C2778010969 @default.
• W2007358788 hasConcept C2778326061 @default.
• W2007358788 hasConcept C2778827303 @default.
• W2007358788 hasConcept C2779610285 @default.
• W2007358788 hasConcept C2780419564 @default.
• W2007358788 hasConcept C2780733407 @default.
• W2007358788 hasConcept C2780771799 @default.
• W2007358788 hasConcept C519581460 @default.
• W2007358788 hasConcept C71924100 @default.
• W2007358788 hasConceptScore W2007358788C120770815 @default.
• W2007358788 hasConceptScore W2007358788C126322002 @default.
• W2007358788 hasConceptScore W2007358788C134018914 @default.
• W2007358788 hasConceptScore W2007358788C173803235 @default.
• W2007358788 hasConceptScore W2007358788C185592680 @default.
• W2007358788 hasConceptScore W2007358788C2775910092 @default.
• W2007358788 hasConceptScore W2007358788C2776820930 @default.
• W2007358788 hasConceptScore W2007358788C2776992346 @default.
• W2007358788 hasConceptScore W2007358788C2777622882 @default.
• W2007358788 hasConceptScore W2007358788C2778010969 @default.
• W2007358788 hasConceptScore W2007358788C2778326061 @default.
• W2007358788 hasConceptScore W2007358788C2778827303 @default.
• W2007358788 hasConceptScore W2007358788C2779610285 @default.
• W2007358788 hasConceptScore W2007358788C2780419564 @default.
• W2007358788 hasConceptScore W2007358788C2780733407 @default.
• W2007358788 hasConceptScore W2007358788C2780771799 @default.
• W2007358788 hasConceptScore W2007358788C519581460 @default.
• W2007358788 hasConceptScore W2007358788C71924100 @default.
• W2007358788 hasIssue "3" @default.
• W2007358788 hasLocation W20073587881 @default.
• W2007358788 hasLocation W20073587882 @default.
• W2007358788 hasLocation W20073587883 @default.
• W2007358788 hasLocation W20073587884 @default.
• W2007358788 hasOpenAccess W2007358788 @default.

• next