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- W2007362519 abstract "The E. coli replication machinery employs a beta clamp that tethers the polymerase to DNA, thus ensuring high processivity. The replicase also contains a processivity switch that dissociates the polymerase from its beta clamp. The switch requires the tau subunit of the clamp loader and is regulated by different DNA structures. At a primed site, the switch is off. When the replicase reaches the downstream primer to form a nick, the switch is flipped, and tau ejects the polymerase from beta. This switch has high fidelity for completed synthesis, remaining off until just prior to incorporation of the last nucleotide and turning on only after addition of the last dNTP. These actions of tau are confined to its C-terminal region, which is located outside the clamp loading apparatus. Thus, this highly processive replication machine has evolved a mechanism to specifically counteract processivity at a defined time in the lagging-strand cycle." @default.
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- W2007362519 date "2003-02-01" @default.
- W2007362519 modified "2023-10-16" @default.
- W2007362519 title "Mechanism of the E. coli τ Processivity Switch during Lagging-Strand Synthesis" @default.
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- W2007362519 doi "https://doi.org/10.1016/s1097-2765(03)00042-x" @default.
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