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• W2007362922 endingPage "1779" @default.
• W2007362922 startingPage "1769" @default.
• W2007362922 abstract "Objective: To determine whether the presence of HLA-C and HLA-E on HIV-infected cells modulates autologous natural killer (NK) cells from implementing antibody-dependent cell-mediated cytotoxicity (ADCC) of HIV-infected cells. Design: The capability of HLA-C and HLA-E to control NK cell killing of HIV-infected autologous T cells coated with anti-gp120 monoclonal antibody was determined by blocking the interaction between the inhibitory receptors on NK cells and the MHC class I molecules on infected cells. Methods: Phytohemagglutinin-treated CD4 T cells were infected in vitro with HIV-1. Infected cells were separated from uninfected cells by removal of CD4 T cells. Infected cells were labeled with chromium-51, treated with a cocktail of four different monoclonal antibodies against HIV gp120, and co-cultured with freshly isolated autologous NK cells that were incubated with or without anti-CD159a, anti-CD158a, and CD158b, or all three antibodies combined. Killing of the HIV-infected cells by NK cells was assessed in a 4 h cytotoxic assay. Results: When the interaction between NK cell inhibitory receptors (i.e., CD158a, CD158b, and CD159a) and MHC class I molecules (i.e., HLA-C and HLA-E) on HIV-infected autologous T cells was blocked, a drastic increase in killing of anti-gp120-coated HIV-infected cells by NK cells was observed. Conclusion: These studies indicate that the presence of HLA-C and HLA-E molecules on HIV-infected cells may facilitate evasion of NK-mediated killing of antibody-coated HIV-infected cells." @default.
• W2007362922 created "2016-06-24" @default.
• W2007362922 creator A5032067061 @default.
• W2007362922 creator A5091801673 @default.
• W2007362922 creator A5091816254 @default.
• W2007362922 date "2004-09-01" @default.
• W2007362922 modified "2023-09-27" @default.
• W2007362922 title "HLA-C and HLA-E reduce antibody-dependent natural killer cell-mediated cytotoxicity of HIV-infected primary T cell blasts" @default.
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• W2007362922 doi "https://doi.org/10.1097/00002030-200409030-00005" @default.
• W2007362922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15316337" @default.
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