Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007363086> ?p ?o ?g. }
- W2007363086 endingPage "6" @default.
- W2007363086 startingPage "1" @default.
- W2007363086 abstract "Abstract The 17HSDs are a group of isozymes that catalyze the interconversion between high‐activity 17β‐hydroxysteroids and low‐activity 17‐ketosteroids. In the present study, we characterized the expression of 17HSD types 1 and 2 in normal and malignant gastrointestinal tissues and cells. Using the colon as a model for cancer of the gastrointestinal tract, expression of the 17HSD enzymes in cancer development was studied and correlated with proliferation and differentiation markers as assessed by Ki67 and mucin staining, respectively. In normal colon and small intestine, 17HSD type 2 mRNA was expressed in the surface epithelial cells and, to a lesser extent, in the cryptal epithelial cells. In colon‐cancer specimens, 17HSD type 2 expression was downregulated both in the tissues and in the cell lines and correlated inversely with the proliferation marker. No expression for the 17HSD type 1 enzyme was observed in normal or cancerous gastrointestinal tract tissues. In line with the expression studies, 17HSD activity measurements with colon cells showed that only the oxidative conversion of E2 to E1 was present, and Northern blot analysis showed the signal only for 17HSD type 2. Localization of the ERs α and β, assessed by immunohistochemistry and in situ hybridization, showed the presence of ERβ in the lamina propria of the colon. Our study shows that 17HSD type 2 expression is associated with the functional integrity of the gastrointestinal tract. The decrease in expression of the type 2 enzyme may increase estrogen influence in colon cancer. © 2002 Wiley‐Liss, Inc." @default.
- W2007363086 created "2016-06-24" @default.
- W2007363086 creator A5002693527 @default.
- W2007363086 creator A5057247134 @default.
- W2007363086 creator A5068196272 @default.
- W2007363086 creator A5086576972 @default.
- W2007363086 creator A5089441396 @default.
- W2007363086 date "2001-12-10" @default.
- W2007363086 modified "2023-10-10" @default.
- W2007363086 title "Downregulation of estrogen-metabolizing 17β-hydroxysteroid dehydrogenase Type 2 expression correlates inversely with Ki67 proliferation marker in colon-cancer development" @default.
- W2007363086 cites W1525342509 @default.
- W2007363086 cites W1833278024 @default.
- W2007363086 cites W1968109674 @default.
- W2007363086 cites W1979071811 @default.
- W2007363086 cites W1982926605 @default.
- W2007363086 cites W1996988163 @default.
- W2007363086 cites W2008724101 @default.
- W2007363086 cites W2009040998 @default.
- W2007363086 cites W2013857643 @default.
- W2007363086 cites W2014265593 @default.
- W2007363086 cites W2014879410 @default.
- W2007363086 cites W2016361058 @default.
- W2007363086 cites W2018466640 @default.
- W2007363086 cites W2029009812 @default.
- W2007363086 cites W2035467252 @default.
- W2007363086 cites W2037097768 @default.
- W2007363086 cites W2039678360 @default.
- W2007363086 cites W2045067238 @default.
- W2007363086 cites W2053311013 @default.
- W2007363086 cites W2057075156 @default.
- W2007363086 cites W2057085338 @default.
- W2007363086 cites W2073005394 @default.
- W2007363086 cites W2074020815 @default.
- W2007363086 cites W2075168643 @default.
- W2007363086 cites W2084383930 @default.
- W2007363086 cites W2091723114 @default.
- W2007363086 cites W2097128357 @default.
- W2007363086 cites W2111482994 @default.
- W2007363086 cites W2116838171 @default.
- W2007363086 cites W2127529986 @default.
- W2007363086 cites W2148234845 @default.
- W2007363086 cites W2155962139 @default.
- W2007363086 cites W2322213171 @default.
- W2007363086 cites W4230809651 @default.
- W2007363086 cites W4233717237 @default.
- W2007363086 cites W4244343848 @default.
- W2007363086 cites W4292230194 @default.
- W2007363086 cites W82721994 @default.
- W2007363086 cites W2023079231 @default.
- W2007363086 doi "https://doi.org/10.1002/ijc.1567" @default.
- W2007363086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11774236" @default.
- W2007363086 hasPublicationYear "2001" @default.
- W2007363086 type Work @default.
- W2007363086 sameAs 2007363086 @default.
- W2007363086 citedByCount "42" @default.
- W2007363086 countsByYear W20073630862013 @default.
- W2007363086 countsByYear W20073630862014 @default.
- W2007363086 countsByYear W20073630862015 @default.
- W2007363086 countsByYear W20073630862016 @default.
- W2007363086 countsByYear W20073630862017 @default.
- W2007363086 countsByYear W20073630862018 @default.
- W2007363086 countsByYear W20073630862019 @default.
- W2007363086 countsByYear W20073630862022 @default.
- W2007363086 crossrefType "journal-article" @default.
- W2007363086 hasAuthorship W2007363086A5002693527 @default.
- W2007363086 hasAuthorship W2007363086A5057247134 @default.
- W2007363086 hasAuthorship W2007363086A5068196272 @default.
- W2007363086 hasAuthorship W2007363086A5086576972 @default.
- W2007363086 hasAuthorship W2007363086A5089441396 @default.
- W2007363086 hasBestOaLocation W20073630861 @default.
- W2007363086 hasConcept C104317684 @default.
- W2007363086 hasConcept C121608353 @default.
- W2007363086 hasConcept C134018914 @default.
- W2007363086 hasConcept C142724271 @default.
- W2007363086 hasConcept C150194340 @default.
- W2007363086 hasConcept C181199279 @default.
- W2007363086 hasConcept C203014093 @default.
- W2007363086 hasConcept C204232928 @default.
- W2007363086 hasConcept C2776317432 @default.
- W2007363086 hasConcept C2777164284 @default.
- W2007363086 hasConcept C2780512811 @default.
- W2007363086 hasConcept C2781067048 @default.
- W2007363086 hasConcept C2909546088 @default.
- W2007363086 hasConcept C526805850 @default.
- W2007363086 hasConcept C54355233 @default.
- W2007363086 hasConcept C55493867 @default.
- W2007363086 hasConcept C71924100 @default.
- W2007363086 hasConcept C81439078 @default.
- W2007363086 hasConcept C86803240 @default.
- W2007363086 hasConceptScore W2007363086C104317684 @default.
- W2007363086 hasConceptScore W2007363086C121608353 @default.
- W2007363086 hasConceptScore W2007363086C134018914 @default.
- W2007363086 hasConceptScore W2007363086C142724271 @default.
- W2007363086 hasConceptScore W2007363086C150194340 @default.
- W2007363086 hasConceptScore W2007363086C181199279 @default.
- W2007363086 hasConceptScore W2007363086C203014093 @default.
- W2007363086 hasConceptScore W2007363086C204232928 @default.
- W2007363086 hasConceptScore W2007363086C2776317432 @default.