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- W2007366962 abstract "To further understand the mechanism by which melatonin potentiates noradrenergic transmission in the rat vas deferens, we localized and partially characterized 2-[125I]-iodomelatonin-binding sites in tissue sections of the rat vas deferens using quantitative autoradiography. High-affinity 2-[125I]-iodomelatonin-binding sites were localized around the lumen of the prostatic portion, but not in the epididymal portion of the rat vas deferens. The binding of 2-[125I]-iodomelatonin to sections of the prostatic portion was stable, reversible and saturable. Saturation studies revealed a single class of high-affinity binding sites with a dissociation constant (Kd) of 104.2 ± 23.7 pM (n = 4) and a binding capacity (Bmax) of 2.07 ±0.19 fmol/mg of protein (n = 4). These results suggest that melatonin may regulate sympathetic neurotransmission through activation of specific melatonin receptors in the prostatic portion of the rat vas deferens." @default.
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- W2007366962 date "1993-01-01" @default.
- W2007366962 modified "2023-09-25" @default.
- W2007366962 title "2-[<sup>125</sup>l]lodomelatonin Binding Sites in the Rat Vas Deferens" @default.
- W2007366962 doi "https://doi.org/10.1159/000109492" @default.
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