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- W2007367040 abstract "Abstract In vitro antimicrobial activity of NM394 (6-fluoro-1-methyl-7-(1-piperazinyl)-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid) against clinical isolates collected from samples (uterine contents, ascites, pus, etc) obtained from patients with obstetric and gynecologic infections was investigated and compared with that of four other quinolones: norfloxacin, ofloxacin, ciprofloxacin, and tosufloxacin. Among 80 strains of aerobes and 60 strains of anaerobes determined, the minimum inhibitory concentrations (MICs) of NM394 for 50% inhibition against methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant S aureus (MRSA), Streptococcus agalactiae, Escherichia coli, Peptostreptococcus magnus, Bacteroides fragilis , and Prevotella bivia were 0.39, 25, 0.78, 0.0125, 0.2, 3.13, and 0.78 μg/mL, respectively, and the MICs for 90% inhibition against MSSA, MRSA, S agalactiae, E coli, P magnus, B fragilis , and P bivia were 1.56, > 100, 1.56, 0.025, 0.39, 6.25, and 1.56 μg/mL, respectively. The antimicrobial activity of NM394 against gram-positive bacteria was less than that of tosufloxacin but was comparable to that of ofloxacin and ciprofloxacin. Judging from its antibacterial activity, the efficacy of NM394 against infections caused by MRSA might be expected to be similar to that of the other four quinolones. The antibacterial activity of NM394 against aerobic gram-negative bacteria, especially E coli , was greater than that of the other new quinolones. However, against anaerobic gram-negative bacteria, especially B fragilis , the antibacterial activity of NM394 appeared to be less than that of the other agents. The clinical implications of these results, if any, remain unknown until further clinical therapeutic trials are conducted." @default.
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- W2007367040 title "Comparative study of in vitro activity of NM394 and four other new quinolones against clinical isolates from patients with obstetric and gynecologic infections" @default.
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- W2007367040 doi "https://doi.org/10.1016/s0011-393x(96)80003-8" @default.
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