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- W2007373071 abstract "The capsule of Cryptococcus neoformans, the principal virulence factor of this fungus, is composed primarily of polysaccharide. The predominant component of the polysaccharide capsule is glucuronoxylomannan (GXM), a compound with potent immunoregulatory properties. GXM is bound and internalized by natural immune cells affecting innate and subsequent adaptive immune response. The cellular pattern recognition receptors involved in GXM binding include toll-like receptor (TLR)4, CD14, TLR2, CD18, Fc gamma receptor II (FcgammaRPi). This multiple cross-linking leads to a suppressive outcome that is arrested and even reversed by protective antibodies to GXM. This review analyzes the immunosuppressive effects induced by capsular material, considering its pattern recognition receptors, and dissects the mechanism of monoclonal antibody shifting to immunoactivation." @default.
- W2007373071 created "2016-06-24" @default.
- W2007373071 creator A5051777748 @default.
- W2007373071 date "2005-06-01" @default.
- W2007373071 modified "2023-09-26" @default.
- W2007373071 title "The Cellular Responses Induced by the Capsular Polysaccharide of Cryptococcus neoformans Differ Depending on the Presence or Absence of Specific Protective Antibodies" @default.
- W2007373071 doi "https://doi.org/10.2174/1566524054022585" @default.
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