FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007376383> ?p ?o ?g. }

• W2007376383 endingPage "330" @default.
• W2007376383 startingPage "323" @default.
• W2007376383 abstract "We showed previously that cAMP response element-binding protein (CREB) within the nucleus accumbens (NAc) of rats regulates immobility in the forced swim test (FST), an assay used to study depression. Because CREB regulates expression of dynorphin (which acts at kappa-opioid receptors) in NAc neurons, these findings raised the possibility that kappa-receptors mediate immobility behaviors in the FST. Here, we report that i.c.v. administration of the kappa-antagonist nor-binaltorphimine dose dependently decreased immobility in the FST, suggesting that it has antidepressant-like effects. Implicating a specific effect at kappa-receptors, similar antidepressant-like effects were seen after treatment with either of two novel, structurally dissimilar kappa-antagonists: 5'-guanidinonaltrindole, which was effective after i.c.v. but not systemic treatment, and 5'-acetamidinoethylnaltrindole (ANTI), which was potent and effective after systemic treatment. The behavioral effects of the kappa-antagonists resembled those of tricyclic antidepressants (desipramine) and selective serotonin reuptake inhibitors (fluoxetine and citalopram). Conversely, systemic administration of the kappa-agonist [5alpha,7alpha,8beta]-N-methyl-N-[7-[1-pyrrolidinyl]-1-oxaspiro[4.5]dec8-yl]-benzenacetamide (U-69593) dose dependently increased immobility in the FST, consistent with prodepressant-like effects. The effects of the kappa-ligands in the FST were not correlated with nonspecific effects on locomotor activity. Furthermore, the most potent and effective kappa-antagonist (ANTI) did not affect the rewarding impact of lateral hypothalamic brain stimulation at a dose with strong antidepressant-like effects. These findings are consistent with the hypothesis that CREB-mediated induction of dynorphin in the NAc triggers immobility behavior in the FST. Furthermore, they raise the possibility that kappa-antagonists may have efficacy as antidepressants, but lack stimulant or reward-related effects." @default.
• W2007376383 created "2016-06-24" @default.
• W2007376383 creator A5003670280 @default.
• W2007376383 creator A5018079253 @default.
• W2007376383 creator A5021145968 @default.
• W2007376383 creator A5024383091 @default.
• W2007376383 creator A5055552050 @default.
• W2007376383 creator A5070230820 @default.
• W2007376383 creator A5086664284 @default.
• W2007376383 creator A5088569638 @default.
• W2007376383 creator A5088862857 @default.
• W2007376383 date "2003-01-21" @default.
• W2007376383 modified "2023-10-16" @default.
• W2007376383 title "Antidepressant-Like Effects of κ-Opioid Receptor Antagonists in the Forced Swim Test in Rats" @default.
• W2007376383 cites W1509868652 @default.
• W2007376383 cites W1671833268 @default.
• W2007376383 cites W1928329059 @default.
• W2007376383 cites W1965435203 @default.
• W2007376383 cites W1968338376 @default.
• W2007376383 cites W1972449722 @default.
• W2007376383 cites W1972849193 @default.
• W2007376383 cites W1983558573 @default.
• W2007376383 cites W1983914274 @default.
• W2007376383 cites W1986331833 @default.
• W2007376383 cites W1998206718 @default.
• W2007376383 cites W2018312069 @default.
• W2007376383 cites W2021213398 @default.
• W2007376383 cites W2021499793 @default.
• W2007376383 cites W2032436575 @default.
• W2007376383 cites W2032643119 @default.
• W2007376383 cites W2038374406 @default.
• W2007376383 cites W2048145838 @default.
• W2007376383 cites W2053472601 @default.
• W2007376383 cites W2057702371 @default.
• W2007376383 cites W2060485896 @default.
• W2007376383 cites W2067020336 @default.
• W2007376383 cites W2070858044 @default.
• W2007376383 cites W2072301923 @default.
• W2007376383 cites W2081843246 @default.
• W2007376383 cites W2084886396 @default.
• W2007376383 cites W2085019729 @default.
• W2007376383 cites W2089299823 @default.
• W2007376383 cites W2089576439 @default.
• W2007376383 cites W2091064555 @default.
• W2007376383 cites W2098580853 @default.
• W2007376383 cites W2143839686 @default.
• W2007376383 cites W2156486511 @default.
• W2007376383 cites W2160829173 @default.
• W2007376383 cites W2165398609 @default.
• W2007376383 cites W2169765156 @default.
• W2007376383 cites W2317914721 @default.
• W2007376383 doi "https://doi.org/10.1124/jpet.102.046433" @default.
• W2007376383 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12649385" @default.
• W2007376383 hasPublicationYear "2003" @default.
• W2007376383 type Work @default.
• W2007376383 sameAs 2007376383 @default.
• W2007376383 citedByCount "452" @default.
• W2007376383 countsByYear W20073763832012 @default.
• W2007376383 countsByYear W20073763832013 @default.
• W2007376383 countsByYear W20073763832014 @default.
• W2007376383 countsByYear W20073763832015 @default.
• W2007376383 countsByYear W20073763832016 @default.
• W2007376383 countsByYear W20073763832017 @default.
• W2007376383 countsByYear W20073763832018 @default.
• W2007376383 countsByYear W20073763832019 @default.
• W2007376383 countsByYear W20073763832020 @default.
• W2007376383 countsByYear W20073763832021 @default.
• W2007376383 countsByYear W20073763832022 @default.
• W2007376383 countsByYear W20073763832023 @default.
• W2007376383 crossrefType "journal-article" @default.
• W2007376383 hasAuthorship W2007376383A5003670280 @default.
• W2007376383 hasAuthorship W2007376383A5018079253 @default.
• W2007376383 hasAuthorship W2007376383A5021145968 @default.
• W2007376383 hasAuthorship W2007376383A5024383091 @default.
• W2007376383 hasAuthorship W2007376383A5055552050 @default.
• W2007376383 hasAuthorship W2007376383A5070230820 @default.
• W2007376383 hasAuthorship W2007376383A5086664284 @default.
• W2007376383 hasAuthorship W2007376383A5088569638 @default.
• W2007376383 hasAuthorship W2007376383A5088862857 @default.
• W2007376383 hasConcept C104317684 @default.
• W2007376383 hasConcept C126322002 @default.
• W2007376383 hasConcept C134018914 @default.
• W2007376383 hasConcept C136569192 @default.
• W2007376383 hasConcept C151077648 @default.
• W2007376383 hasConcept C1629964 @default.
• W2007376383 hasConcept C170493617 @default.
• W2007376383 hasConcept C184389661 @default.
• W2007376383 hasConcept C185592680 @default.
• W2007376383 hasConcept C2775864247 @default.
• W2007376383 hasConcept C2776552330 @default.
• W2007376383 hasConcept C2776885963 @default.
• W2007376383 hasConcept C2777490545 @default.
• W2007376383 hasConcept C2778938600 @default.
• W2007376383 hasConcept C2779177272 @default.
• W2007376383 hasConcept C2780250439 @default.
• W2007376383 hasConcept C2781001258 @default.
• W2007376383 hasConcept C2781063702 @default.
• W2007376383 hasConcept C2781161787 @default.

• next