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- W2007377453 abstract "Clostridium difficile is a major cause of antibiotic-associated diarrhoea and the primary cause of psedomembraneous colitis in hospitalised patients. We assessed the protective effect of anti-surface layer protein (SLP) antibodies on C. difficile infection in a lethal hamster challenge model. Post-challenge survival was significantly prolonged in the anti-SLP treated group compared with control groups (P= 0.0281 and P= 0.0283). The potential mechanism of action of the antiserum was shown to be through enhancement of C. difficile phagocytosis. This report indicates that anti-SLP antibodies can modulate the course of C. difficile infection and may therefore merit closer investigation for use as constituents of multi-component vaccines against C. difficile associated diarrhoea." @default.
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- W2007377453 date "2005-05-01" @default.
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- W2007377453 title "Passive immunisation of hamsters against<i>Clostridium difficile</i>infection using antibodies to surface layer proteins" @default.
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- W2007377453 doi "https://doi.org/10.1016/j.femsle.2005.04.005" @default.
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