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- W2007379469 abstract "Complete Freund’s adjuvant (CFA) administered before sensitization dampened the normal and cyclophosphamide-enhanced response of high and moderate IgE responder phenotype mice (CAF<sub>1</sub> and C57Bl/6J, respectively). CFA-induced suppression of IgE biosynthesis was effective in reducing anaphylactic histamine release from ∼2,900 ng histamine per milliliter to background levels (<100 ng/ml). CFA-induced ascites fluid was able to reduce the cyclophosphamide-enhanced IgE response of low-responder phenotype SJL mice from 1:320 to <1:5 as determined by passive cutaneous anaphylaxis. Muramyl dipeptide, a mycobacterial cell wall component capable of eliciting effects similar to those seen with CFA, was shown to induce suppression of IgE production if incorporated in incomplete Freund’s adjuvant. Muramyl dipeptide administered in saline was ineffective, while incomplete Freund’s adjuvant alone had some immunoregulatory properties. Ongoing IgE responses were less susceptible to regulation. CFA administered to sensitized C57Bl/6J mice was ineffective in inducing IgE suppression when animals were challenged with antigen." @default.
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- W2007379469 date "1986-01-01" @default.
- W2007379469 modified "2023-10-18" @default.
- W2007379469 title "Regulation of in vivo IgE Biosynthesis in Mice with Complete Freund’s Adjuvant" @default.
- W2007379469 doi "https://doi.org/10.1159/000233999" @default.
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