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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007384249> ?p ?o ?g. }

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• W2007384249 abstract "We describe the design, synthesis and SAR profiling of a series of novel combretastatin–nocodazole conjugates as potential anticancer agents. The thiophene ring in the nocodazole moiety was replaced by a substituted phenyl ring from the combretastatin moiety to design novel hybrid analogues. The hydroxyl group at the ortho position in compounds 2, 3 and 4 was used as the conformationally locking tool by anticipated six-membered hydrogen bonding. The bioactivity profiles of all compounds as tubulin polymerization inhibitors and as antiproliferative agents against the A-549 human lung cancer cell line were investigated Compounds 1 and 4 showed μM IC50 values in both assays." @default.
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• W2007384249 date "2015-05-01" @default.
• W2007384249 modified "2023-10-06" @default.
• W2007384249 title "Novel hybrid nocodazole analogues as tubulin polymerization inhibitors and their antiproliferative activity" @default.
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• W2007384249 doi "https://doi.org/10.1016/j.bmcl.2015.03.019" @default.
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