FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007392903> ?p ?o ?g. }

• W2007392903 endingPage "273" @default.
• W2007392903 startingPage "268" @default.
• W2007392903 abstract "Over-activation of ionotropic glutamate receptors can cause an excessive influx of calcium ions into neurons, which subsequently triggers the degeneration and death of cells in a process known as excitotoxicity. Here, we examined the effects of modulating ionotropic glutamate receptors and L-type voltage-gated calcium channels (L-VGCC) on the expression and activation of c-Jun in hippocampus of SD rats after transient global ischemia. The total protein of c-Jun was altered by ischemia–reperfusion and reached its high levels at 3–6 h of reperfusion. However, the increased expression was prevented by pretreatment of ketamine (a non-competitive N-methyl-d-aspartate (NMDA) receptors antagonist) or nifedipine (a blocker of L-VGCC), but not by 6,7-dinitroquinoxaline-2,3(1H,4H)-dione (DNQX), an AMPA/KA receptor antagonist. On the other hand, c-Jun phosphorylation was significantly increased 3 h after reperfusion, which was inhibited by DNQX, but not ketamine or nifedipine. AP-1 binding activity reactions were also performed by electrophoretic mobility shift assay (EMSA), which detected similar results as those in Western blotting. Our results clearly showed that c-Jun expression is NMDA receptor/L-VGCC-dependent and c-Jun activation is AMPA/KA receptor-dependent, which expands our knowledge of the JNK-c-Jun signaling pathway in ischemic brain damage." @default.
• W2007392903 created "2016-06-24" @default.
• W2007392903 creator A5004018366 @default.
• W2007392903 creator A5008880759 @default.
• W2007392903 creator A5023313076 @default.
• W2007392903 creator A5035114964 @default.
• W2007392903 creator A5077923179 @default.
• W2007392903 date "2006-05-01" @default.
• W2007392903 modified "2023-10-12" @default.
• W2007392903 title "NMDA receptor/L-VGCC-dependent expression and AMPA/KA receptor-dependent activation of c-Jun induced by cerebral ischemia in rat hippocampus" @default.
• W2007392903 cites W1522813904 @default.
• W2007392903 cites W1530284699 @default.
• W2007392903 cites W1965295649 @default.
• W2007392903 cites W1967463041 @default.
• W2007392903 cites W1976436672 @default.
• W2007392903 cites W1979697286 @default.
• W2007392903 cites W1986543684 @default.
• W2007392903 cites W1990452376 @default.
• W2007392903 cites W2005423627 @default.
• W2007392903 cites W2009297045 @default.
• W2007392903 cites W2018096243 @default.
• W2007392903 cites W2025581014 @default.
• W2007392903 cites W2049468477 @default.
• W2007392903 cites W2054405716 @default.
• W2007392903 cites W2070948501 @default.
• W2007392903 cites W2072926617 @default.
• W2007392903 cites W2086507786 @default.
• W2007392903 cites W2094580582 @default.
• W2007392903 cites W2118897660 @default.
• W2007392903 cites W2129388998 @default.
• W2007392903 cites W2132007064 @default.
• W2007392903 cites W2134859746 @default.
• W2007392903 cites W2139488506 @default.
• W2007392903 cites W2147741867 @default.
• W2007392903 doi "https://doi.org/10.1016/j.neulet.2006.01.005" @default.
• W2007392903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16448753" @default.
• W2007392903 hasPublicationYear "2006" @default.
• W2007392903 type Work @default.
• W2007392903 sameAs 2007392903 @default.
• W2007392903 citedByCount "14" @default.
• W2007392903 countsByYear W20073929032013 @default.
• W2007392903 countsByYear W20073929032014 @default.
• W2007392903 countsByYear W20073929032015 @default.
• W2007392903 countsByYear W20073929032016 @default.
• W2007392903 countsByYear W20073929032017 @default.
• W2007392903 countsByYear W20073929032019 @default.
• W2007392903 countsByYear W20073929032020 @default.
• W2007392903 countsByYear W20073929032021 @default.
• W2007392903 crossrefType "journal-article" @default.
• W2007392903 hasAuthorship W2007392903A5004018366 @default.
• W2007392903 hasAuthorship W2007392903A5008880759 @default.
• W2007392903 hasAuthorship W2007392903A5023313076 @default.
• W2007392903 hasAuthorship W2007392903A5035114964 @default.
• W2007392903 hasAuthorship W2007392903A5077923179 @default.
• W2007392903 hasConcept C115955781 @default.
• W2007392903 hasConcept C126322002 @default.
• W2007392903 hasConcept C134018914 @default.
• W2007392903 hasConcept C160268369 @default.
• W2007392903 hasConcept C170493617 @default.
• W2007392903 hasConcept C185592680 @default.
• W2007392903 hasConcept C189184402 @default.
• W2007392903 hasConcept C2777075645 @default.
• W2007392903 hasConcept C2780076171 @default.
• W2007392903 hasConcept C2781012912 @default.
• W2007392903 hasConcept C55493867 @default.
• W2007392903 hasConcept C61174792 @default.
• W2007392903 hasConcept C67018056 @default.
• W2007392903 hasConcept C71924100 @default.
• W2007392903 hasConcept C86803240 @default.
• W2007392903 hasConcept C98274493 @default.
• W2007392903 hasConceptScore W2007392903C115955781 @default.
• W2007392903 hasConceptScore W2007392903C126322002 @default.
• W2007392903 hasConceptScore W2007392903C134018914 @default.
• W2007392903 hasConceptScore W2007392903C160268369 @default.
• W2007392903 hasConceptScore W2007392903C170493617 @default.
• W2007392903 hasConceptScore W2007392903C185592680 @default.
• W2007392903 hasConceptScore W2007392903C189184402 @default.
• W2007392903 hasConceptScore W2007392903C2777075645 @default.
• W2007392903 hasConceptScore W2007392903C2780076171 @default.
• W2007392903 hasConceptScore W2007392903C2781012912 @default.
• W2007392903 hasConceptScore W2007392903C55493867 @default.
• W2007392903 hasConceptScore W2007392903C61174792 @default.
• W2007392903 hasConceptScore W2007392903C67018056 @default.
• W2007392903 hasConceptScore W2007392903C71924100 @default.
• W2007392903 hasConceptScore W2007392903C86803240 @default.
• W2007392903 hasConceptScore W2007392903C98274493 @default.
• W2007392903 hasIssue "3" @default.
• W2007392903 hasLocation W20073929031 @default.
• W2007392903 hasLocation W20073929032 @default.
• W2007392903 hasOpenAccess W2007392903 @default.
• W2007392903 hasPrimaryLocation W20073929031 @default.
• W2007392903 hasRelatedWork W1994102760 @default.
• W2007392903 hasRelatedWork W2034022242 @default.
• W2007392903 hasRelatedWork W2037894465 @default.
• W2007392903 hasRelatedWork W2051188198 @default.
• W2007392903 hasRelatedWork W2061803830 @default.
• W2007392903 hasRelatedWork W2068307574 @default.
• W2007392903 hasRelatedWork W2077526075 @default.

• next