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- W2007393668 abstract "The present study examined the neuroprotective effects of choroid plexus isolated from adult rats and encapsulated within alginate microcapsules. In vitro, conditioned media from cultured choroid plexus produced a marked, dose-dependant protection of embryonic cortical neurons against serum deprivation-induced cell death. In vivo studies demonstrated that a one-hour middle cerebral artery occlusion in adult Wistar rats produced profound motor and neurological impairments 1–3 days after stroke. In contrast, stroke animals transplanted with encapsulated choroid plexus cells displayed a significant reduction in both motor and neurological abnormalities. Histological analysis 3 days post-transplantation revealed that choroid plexus transplants significantly decreased the volume of striatal infarction. This is the first report demonstrating the therapeutic potential of transplanted choroid plexus for stroke." @default.
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- W2007393668 date "2004-07-19" @default.
- W2007393668 modified "2023-10-11" @default.
- W2007393668 title "CNS grafts of rat choroid plexus protect against cerebral ischemia in adult rats" @default.
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- W2007393668 doi "https://doi.org/10.1097/01.wnr.0000133298.84901.cf" @default.
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