Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007393951> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2007393951 endingPage "252" @default.
- W2007393951 startingPage "247" @default.
- W2007393951 abstract "A case of chronic myelogenous leukemia (CML) is described whose leukemic cells appeared to contain two Philadelphia (Ph) chromosomes originating from different translocations involving the two chromosomes 22. The karyotype of the affected cells, established on two different occasions, was: 46,XY,t(9;22)(q34;q11),t(15;22)(p11;q11) with no normal chromosomes 22 and only one 9q+ in each of 115 marrow cells examined. The same findings were present in 50 peripheral blood cells cultured without phytohemagglutinin (PHA) stimulation. When stimulated with PHA, a normal male karyotype was present in the 11 cells examined. There were no additional chromosomal abnormalities and no indication of a blastic crisis after nearly 1 year following the original study. Analysis of the breakpoint cluster region (bcr) on chromosome 22 in the DNA of the affected cells (marrow) revealed evidence for one rearranged chromosome 22 and one normal chromosome 22, indicating that the t(15;22) was not due to the usual Ph translocation seen in CML. The results point to the crucial usefulness of molecular analysis in confirming cytogenetic results related to Ph translocations in CML." @default.
- W2007393951 created "2016-06-24" @default.
- W2007393951 creator A5002772088 @default.
- W2007393951 creator A5026531298 @default.
- W2007393951 creator A5031335334 @default.
- W2007393951 creator A5034257093 @default.
- W2007393951 creator A5060398064 @default.
- W2007393951 creator A5061430289 @default.
- W2007393951 creator A5067302099 @default.
- W2007393951 creator A5075174835 @default.
- W2007393951 date "1991-07-01" @default.
- W2007393951 modified "2023-09-23" @default.
- W2007393951 title "Molecular differentiation of two different translocations producing two apparent Ph chromosomes in a patient with CML" @default.
- W2007393951 cites W1525850954 @default.
- W2007393951 cites W1998593414 @default.
- W2007393951 cites W2035165731 @default.
- W2007393951 cites W2077503499 @default.
- W2007393951 cites W2307922867 @default.
- W2007393951 doi "https://doi.org/10.1016/0165-4608(91)90215-g" @default.
- W2007393951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1884359" @default.
- W2007393951 hasPublicationYear "1991" @default.
- W2007393951 type Work @default.
- W2007393951 sameAs 2007393951 @default.
- W2007393951 citedByCount "1" @default.
- W2007393951 crossrefType "journal-article" @default.
- W2007393951 hasAuthorship W2007393951A5002772088 @default.
- W2007393951 hasAuthorship W2007393951A5026531298 @default.
- W2007393951 hasAuthorship W2007393951A5031335334 @default.
- W2007393951 hasAuthorship W2007393951A5034257093 @default.
- W2007393951 hasAuthorship W2007393951A5060398064 @default.
- W2007393951 hasAuthorship W2007393951A5061430289 @default.
- W2007393951 hasAuthorship W2007393951A5067302099 @default.
- W2007393951 hasAuthorship W2007393951A5075174835 @default.
- W2007393951 hasConcept C104317684 @default.
- W2007393951 hasConcept C138626823 @default.
- W2007393951 hasConcept C153911025 @default.
- W2007393951 hasConcept C174475383 @default.
- W2007393951 hasConcept C2776960273 @default.
- W2007393951 hasConcept C2778461978 @default.
- W2007393951 hasConcept C2778904597 @default.
- W2007393951 hasConcept C30481170 @default.
- W2007393951 hasConcept C43907098 @default.
- W2007393951 hasConcept C53226629 @default.
- W2007393951 hasConcept C54355233 @default.
- W2007393951 hasConcept C86803240 @default.
- W2007393951 hasConceptScore W2007393951C104317684 @default.
- W2007393951 hasConceptScore W2007393951C138626823 @default.
- W2007393951 hasConceptScore W2007393951C153911025 @default.
- W2007393951 hasConceptScore W2007393951C174475383 @default.
- W2007393951 hasConceptScore W2007393951C2776960273 @default.
- W2007393951 hasConceptScore W2007393951C2778461978 @default.
- W2007393951 hasConceptScore W2007393951C2778904597 @default.
- W2007393951 hasConceptScore W2007393951C30481170 @default.
- W2007393951 hasConceptScore W2007393951C43907098 @default.
- W2007393951 hasConceptScore W2007393951C53226629 @default.
- W2007393951 hasConceptScore W2007393951C54355233 @default.
- W2007393951 hasConceptScore W2007393951C86803240 @default.
- W2007393951 hasIssue "2" @default.
- W2007393951 hasLocation W20073939511 @default.
- W2007393951 hasLocation W20073939512 @default.
- W2007393951 hasOpenAccess W2007393951 @default.
- W2007393951 hasPrimaryLocation W20073939511 @default.
- W2007393951 hasRelatedWork W182575250 @default.
- W2007393951 hasRelatedWork W1966077681 @default.
- W2007393951 hasRelatedWork W1966396612 @default.
- W2007393951 hasRelatedWork W1993703063 @default.
- W2007393951 hasRelatedWork W1999860130 @default.
- W2007393951 hasRelatedWork W2007393951 @default.
- W2007393951 hasRelatedWork W2019685656 @default.
- W2007393951 hasRelatedWork W2070973304 @default.
- W2007393951 hasRelatedWork W2087768652 @default.
- W2007393951 hasRelatedWork W2093913151 @default.
- W2007393951 hasVolume "54" @default.
- W2007393951 isParatext "false" @default.
- W2007393951 isRetracted "false" @default.
- W2007393951 magId "2007393951" @default.
- W2007393951 workType "article" @default.