FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007395718> ?p ?o ?g. }

• W2007395718 endingPage "211" @default.
• W2007395718 startingPage "203" @default.
• W2007395718 abstract "Abnormal accumulation of neurofilaments in motor neurons is a characteristic pathological finding in amyotrophic lateral sclerosis (ALS). Recently, we revealed that galectin-1, whose oxidized form has axonal regeneration-enhancing activity, accumulates in the neurofilamentous lesions in ALS. To investigate whether oxidized galectin-1 has a beneficial effect on ALS, oxidized recombinant human galectin-1 (rhGAL-1/ox) or physiological saline was injected into the left gastrocnemius muscle of the transgenic mice over-expressing a mutant copper/zinc superoxide dismutase (SOD1) with a substitution of histidine to arginine at position 46 (H46R SOD1). The H46R SOD1 transgenic mice, which represented a new animal model of familial ALS, were subsequently assessed for their disease onset, life span, duration of illness, and motor function. Furthermore, the number of remaining large anterior horn cells of spinal cords was also compared between the two groups. The results showed that administration of rhGAL-1/ox to the mice delayed the onset of their disease and prolonged the life of the mice and the duration of their illness. Motor function, as evaluated by a Rotarod performance, was improved in rhGAL-1/ox-treated mice. Significantly more anterior horn neurons of the lumbar and cervical cords were preserved in the mice injected with rhGAL-1/ox than in those injected with physiological saline. The study suggests that rhGAL-1/ox administration could be a new therapeutic strategy for ALS." @default.
• W2007395718 created "2016-06-24" @default.
• W2007395718 creator A5009546157 @default.
• W2007395718 creator A5013310458 @default.
• W2007395718 creator A5015711180 @default.
• W2007395718 creator A5041503950 @default.
• W2007395718 creator A5050470835 @default.
• W2007395718 creator A5051575733 @default.
• W2007395718 creator A5051779733 @default.
• W2007395718 creator A5073117349 @default.
• W2007395718 creator A5075755384 @default.
• W2007395718 creator A5081719901 @default.
• W2007395718 creator A5083241761 @default.
• W2007395718 date "2005-07-01" @default.
• W2007395718 modified "2023-09-23" @default.
• W2007395718 title "Neuroprotective effect of oxidized galectin-1 in a transgenic mouse model of amyotrophic lateral sclerosis" @default.
• W2007395718 cites W1516659005 @default.
• W2007395718 cites W1565043637 @default.
• W2007395718 cites W1931706129 @default.
• W2007395718 cites W1960735897 @default.
• W2007395718 cites W1967237152 @default.
• W2007395718 cites W1981314240 @default.
• W2007395718 cites W1992173766 @default.
• W2007395718 cites W1995075942 @default.
• W2007395718 cites W1995352629 @default.
• W2007395718 cites W2002104055 @default.
• W2007395718 cites W2007458789 @default.
• W2007395718 cites W2013135033 @default.
• W2007395718 cites W2013473672 @default.
• W2007395718 cites W2017222498 @default.
• W2007395718 cites W2021374516 @default.
• W2007395718 cites W2022367303 @default.
• W2007395718 cites W2035588799 @default.
• W2007395718 cites W2037024974 @default.
• W2007395718 cites W204358047 @default.
• W2007395718 cites W2044384158 @default.
• W2007395718 cites W2049135007 @default.
• W2007395718 cites W2059087870 @default.
• W2007395718 cites W2064120530 @default.
• W2007395718 cites W2065212541 @default.
• W2007395718 cites W2068201081 @default.
• W2007395718 cites W2070243481 @default.
• W2007395718 cites W2070468963 @default.
• W2007395718 cites W2071926124 @default.
• W2007395718 cites W2077003408 @default.
• W2007395718 cites W2093377540 @default.
• W2007395718 cites W2095997494 @default.
• W2007395718 cites W2098750607 @default.
• W2007395718 cites W2105221685 @default.
• W2007395718 cites W2106526071 @default.
• W2007395718 cites W2107768418 @default.
• W2007395718 cites W2133400638 @default.
• W2007395718 cites W2146421447 @default.
• W2007395718 cites W2291020498 @default.
• W2007395718 cites W2293113121 @default.
• W2007395718 cites W4236884331 @default.
• W2007395718 doi "https://doi.org/10.1016/j.expneurol.2005.02.011" @default.
• W2007395718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15899257" @default.
• W2007395718 hasPublicationYear "2005" @default.
• W2007395718 type Work @default.
• W2007395718 sameAs 2007395718 @default.
• W2007395718 citedByCount "54" @default.
• W2007395718 countsByYear W20073957182012 @default.
• W2007395718 countsByYear W20073957182013 @default.
• W2007395718 countsByYear W20073957182014 @default.
• W2007395718 countsByYear W20073957182015 @default.
• W2007395718 countsByYear W20073957182016 @default.
• W2007395718 countsByYear W20073957182017 @default.
• W2007395718 countsByYear W20073957182018 @default.
• W2007395718 countsByYear W20073957182019 @default.
• W2007395718 countsByYear W20073957182020 @default.
• W2007395718 countsByYear W20073957182021 @default.
• W2007395718 countsByYear W20073957182022 @default.
• W2007395718 crossrefType "journal-article" @default.
• W2007395718 hasAuthorship W2007395718A5009546157 @default.
• W2007395718 hasAuthorship W2007395718A5013310458 @default.
• W2007395718 hasAuthorship W2007395718A5015711180 @default.
• W2007395718 hasAuthorship W2007395718A5041503950 @default.
• W2007395718 hasAuthorship W2007395718A5050470835 @default.
• W2007395718 hasAuthorship W2007395718A5051575733 @default.
• W2007395718 hasAuthorship W2007395718A5051779733 @default.
• W2007395718 hasAuthorship W2007395718A5073117349 @default.
• W2007395718 hasAuthorship W2007395718A5075755384 @default.
• W2007395718 hasAuthorship W2007395718A5081719901 @default.
• W2007395718 hasAuthorship W2007395718A5083241761 @default.
• W2007395718 hasConcept C102230213 @default.
• W2007395718 hasConcept C104317684 @default.
• W2007395718 hasConcept C126322002 @default.
• W2007395718 hasConcept C134018914 @default.
• W2007395718 hasConcept C141035611 @default.
• W2007395718 hasConcept C142724271 @default.
• W2007395718 hasConcept C157207234 @default.
• W2007395718 hasConcept C169760540 @default.
• W2007395718 hasConcept C185592680 @default.
• W2007395718 hasConcept C204232928 @default.
• W2007395718 hasConcept C25498285 @default.
• W2007395718 hasConcept C2775838275 @default.
• W2007395718 hasConcept C2776151105 @default.

• next