FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007400388> ?p ?o ?g. }

• W2007400388 endingPage "e31174" @default.
• W2007400388 startingPage "e31174" @default.
• W2007400388 abstract "Severe liver injury that occurs when immune cells mistakenly attack an individual's own liver cells leads to autoimmune hepatitis. In mice, acute hepatitis can be induced by concanavalin A (ConA) treatment, which causes rapid activation of CD1d-positive natural killer (NK) T cells. These activated NKT cells produce large amounts of cytokines, which induce strong inflammation that damages liver tissues. Here we show that PKC-θ(-/-) mice were resistant to ConA-induced hepatitis due to essential function of PKC-θ in NKT cell development and activation. A dosage of ConA (25 mg/kg) that was lethal to wild-type (WT) mice failed to induce death resulting from liver injury in PKC-θ(-/-) mice. Correspondingly, ConA-induced production of cytokines such as IFNγ, IL-6, and TNFα, which mediate the inflammation responsible for liver injury, were significantly lower in PKC-θ(-/-) mice. Peripheral NKT cells had developmental defects at early stages in the thymus in PKC-θ(-/-) mice, and as a result their frequency and number were greatly reduced. Furthermore, PKC-θ(-/-) bone marrow adoptively transferred to WT mice displayed similar defects in NKT cell development, suggesting an intrinsic requirement for PKC-θ in NKT cell development. In addition, upon stimulation with NKT cell-specific lipid ligand, peripheral PKC-θ(-/-) NKT cells produced lower levels of inflammatory cytokines than that of WT NKT cells, suggesting that activation of NKT cells also requires PKC-θ. Our results suggest PKC-θ is an essential molecule required for activation of NKT cell to induce hepatitis, and thus, is a potential drug target for prevention of autoimmune hepatitis." @default.
• W2007400388 created "2016-06-24" @default.
• W2007400388 creator A5006121037 @default.
• W2007400388 creator A5007825697 @default.
• W2007400388 creator A5019041035 @default.
• W2007400388 creator A5043533892 @default.
• W2007400388 creator A5050736098 @default.
• W2007400388 creator A5078109266 @default.
• W2007400388 date "2012-02-07" @default.
• W2007400388 modified "2023-10-14" @default.
• W2007400388 title "Ameliorated ConA-Induced Hepatitis in the Absence of PKC-theta" @default.
• W2007400388 cites W1528310389 @default.
• W2007400388 cites W1551067065 @default.
• W2007400388 cites W1794979908 @default.
• W2007400388 cites W1900386759 @default.
• W2007400388 cites W1970548110 @default.
• W2007400388 cites W1980050556 @default.
• W2007400388 cites W1995354641 @default.
• W2007400388 cites W1999653497 @default.
• W2007400388 cites W2002696696 @default.
• W2007400388 cites W2006848339 @default.
• W2007400388 cites W2011128327 @default.
• W2007400388 cites W2013255473 @default.
• W2007400388 cites W2015337271 @default.
• W2007400388 cites W2021911222 @default.
• W2007400388 cites W2023239509 @default.
• W2007400388 cites W2025575764 @default.
• W2007400388 cites W2035487460 @default.
• W2007400388 cites W2040293152 @default.
• W2007400388 cites W2041181665 @default.
• W2007400388 cites W2045631856 @default.
• W2007400388 cites W2046746241 @default.
• W2007400388 cites W2053208260 @default.
• W2007400388 cites W2054438783 @default.
• W2007400388 cites W2071417089 @default.
• W2007400388 cites W2076382815 @default.
• W2007400388 cites W2082494360 @default.
• W2007400388 cites W2088608418 @default.
• W2007400388 cites W2097139406 @default.
• W2007400388 cites W2112133459 @default.
• W2007400388 cites W2121477549 @default.
• W2007400388 cites W2123742933 @default.
• W2007400388 cites W2138375420 @default.
• W2007400388 cites W2138453840 @default.
• W2007400388 cites W2144935474 @default.
• W2007400388 cites W2144952980 @default.
• W2007400388 cites W2145060265 @default.
• W2007400388 cites W2151795220 @default.
• W2007400388 cites W2153227360 @default.
• W2007400388 cites W2154882161 @default.
• W2007400388 cites W2155174618 @default.
• W2007400388 cites W2166570978 @default.
• W2007400388 doi "https://doi.org/10.1371/journal.pone.0031174" @default.
• W2007400388 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3274545" @default.
• W2007400388 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22347449" @default.
• W2007400388 hasPublicationYear "2012" @default.
• W2007400388 type Work @default.
• W2007400388 sameAs 2007400388 @default.
• W2007400388 citedByCount "22" @default.
• W2007400388 countsByYear W20074003882012 @default.
• W2007400388 countsByYear W20074003882013 @default.
• W2007400388 countsByYear W20074003882014 @default.
• W2007400388 countsByYear W20074003882015 @default.
• W2007400388 countsByYear W20074003882016 @default.
• W2007400388 countsByYear W20074003882017 @default.
• W2007400388 countsByYear W20074003882018 @default.
• W2007400388 countsByYear W20074003882020 @default.
• W2007400388 countsByYear W20074003882021 @default.
• W2007400388 countsByYear W20074003882022 @default.
• W2007400388 countsByYear W20074003882023 @default.
• W2007400388 crossrefType "journal-article" @default.
• W2007400388 hasAuthorship W2007400388A5006121037 @default.
• W2007400388 hasAuthorship W2007400388A5007825697 @default.
• W2007400388 hasAuthorship W2007400388A5019041035 @default.
• W2007400388 hasAuthorship W2007400388A5043533892 @default.
• W2007400388 hasAuthorship W2007400388A5050736098 @default.
• W2007400388 hasAuthorship W2007400388A5078109266 @default.
• W2007400388 hasBestOaLocation W20074003881 @default.
• W2007400388 hasConcept C134018914 @default.
• W2007400388 hasConcept C139563560 @default.
• W2007400388 hasConcept C185592680 @default.
• W2007400388 hasConcept C19869320 @default.
• W2007400388 hasConcept C202751555 @default.
• W2007400388 hasConcept C203014093 @default.
• W2007400388 hasConcept C2776029263 @default.
• W2007400388 hasConcept C2776090121 @default.
• W2007400388 hasConcept C2776637226 @default.
• W2007400388 hasConcept C2776914184 @default.
• W2007400388 hasConcept C55493867 @default.
• W2007400388 hasConcept C86803240 @default.
• W2007400388 hasConcept C8891405 @default.
• W2007400388 hasConcept C95444343 @default.
• W2007400388 hasConceptScore W2007400388C134018914 @default.
• W2007400388 hasConceptScore W2007400388C139563560 @default.
• W2007400388 hasConceptScore W2007400388C185592680 @default.
• W2007400388 hasConceptScore W2007400388C19869320 @default.
• W2007400388 hasConceptScore W2007400388C202751555 @default.
• W2007400388 hasConceptScore W2007400388C203014093 @default.

• next