FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007401421> ?p ?o ?g. }

• W2007401421 endingPage "282" @default.
• W2007401421 startingPage "273" @default.
• W2007401421 abstract "Population bottlenecks are stochastic events that strongly condition the structure and evolution of natural populations. Their effects are readily observable in highly heterogeneous populations, such as RNA viruses, since bottlenecks cause a fast accumulation of mutations. Considering that most mutations are deleterious, it was predicted that the frequent application of bottlenecks would yield a population unable to replicate. However, in vitro as well as in vivo systems evolving through bottlenecks present a remarkable resistance to extinction. This observation reveals the robustness of RNA viruses and points to the existence of internal mechanisms which must confer a high degree of adaptability to fast mutating populations. In this contribution, we review experimental observations regarding the survival of RNA viruses, both in laboratory experiments and in natural populations. By means of a simple theoretical model of evolution which incorporates strong reductions of the population size, we explore the relationship between the number of replication rounds that a single founder particle undergoes before the next bottleneck is applied, and the mutation rate in a particular environment. Our numerical results reveal that the mutation rate has evolved in a concerted way with the degree of optimization achieved by the population originated from the founder particle. We hypothesize that this mechanism generates a mutation-selection equilibrium in natural populations that maximizes adaptability while maintaining their structure." @default.
• W2007401421 created "2016-06-24" @default.
• W2007401421 creator A5010609839 @default.
• W2007401421 creator A5053165669 @default.
• W2007401421 creator A5056385445 @default.
• W2007401421 creator A5065031918 @default.
• W2007401421 date "2005-03-01" @default.
• W2007401421 modified "2023-09-30" @default.
• W2007401421 title "High mutation rates, bottlenecks, and robustness of RNA viral quasispecies" @default.
• W2007401421 cites W1927182800 @default.
• W2007401421 cites W1935879993 @default.
• W2007401421 cites W1971541535 @default.
• W2007401421 cites W1978146026 @default.
• W2007401421 cites W1981105411 @default.
• W2007401421 cites W1990653767 @default.
• W2007401421 cites W1991729182 @default.
• W2007401421 cites W1994227589 @default.
• W2007401421 cites W2001505139 @default.
• W2007401421 cites W2018291578 @default.
• W2007401421 cites W2021132008 @default.
• W2007401421 cites W2030121089 @default.
• W2007401421 cites W2032402861 @default.
• W2007401421 cites W2035420681 @default.
• W2007401421 cites W2045716211 @default.
• W2007401421 cites W2048499136 @default.
• W2007401421 cites W2053109557 @default.
• W2007401421 cites W2055633360 @default.
• W2007401421 cites W2061089511 @default.
• W2007401421 cites W2064695585 @default.
• W2007401421 cites W2066910967 @default.
• W2007401421 cites W2089751554 @default.
• W2007401421 cites W2093031223 @default.
• W2007401421 cites W2096519756 @default.
• W2007401421 cites W2097295643 @default.
• W2007401421 cites W2098504825 @default.
• W2007401421 cites W2101614244 @default.
• W2007401421 cites W2114870795 @default.
• W2007401421 cites W2116597211 @default.
• W2007401421 cites W2118489430 @default.
• W2007401421 cites W2128868625 @default.
• W2007401421 cites W2141208938 @default.
• W2007401421 cites W2153918414 @default.
• W2007401421 cites W2154022229 @default.
• W2007401421 cites W2169720246 @default.
• W2007401421 cites W4234157714 @default.
• W2007401421 doi "https://doi.org/10.1016/j.gene.2004.12.033" @default.
• W2007401421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15777632" @default.
• W2007401421 hasPublicationYear "2005" @default.
• W2007401421 type Work @default.
• W2007401421 sameAs 2007401421 @default.
• W2007401421 citedByCount "88" @default.
• W2007401421 countsByYear W20074014212012 @default.
• W2007401421 countsByYear W20074014212013 @default.
• W2007401421 countsByYear W20074014212014 @default.
• W2007401421 countsByYear W20074014212015 @default.
• W2007401421 countsByYear W20074014212016 @default.
• W2007401421 countsByYear W20074014212017 @default.
• W2007401421 countsByYear W20074014212018 @default.
• W2007401421 countsByYear W20074014212019 @default.
• W2007401421 countsByYear W20074014212020 @default.
• W2007401421 countsByYear W20074014212021 @default.
• W2007401421 countsByYear W20074014212022 @default.
• W2007401421 countsByYear W20074014212023 @default.
• W2007401421 crossrefType "journal-article" @default.
• W2007401421 hasAuthorship W2007401421A5010609839 @default.
• W2007401421 hasAuthorship W2007401421A5053165669 @default.
• W2007401421 hasAuthorship W2007401421A5056385445 @default.
• W2007401421 hasAuthorship W2007401421A5065031918 @default.
• W2007401421 hasConcept C104317684 @default.
• W2007401421 hasConcept C141231307 @default.
• W2007401421 hasConcept C144024400 @default.
• W2007401421 hasConcept C14500911 @default.
• W2007401421 hasConcept C149923435 @default.
• W2007401421 hasConcept C177606310 @default.
• W2007401421 hasConcept C18903297 @default.
• W2007401421 hasConcept C2779174946 @default.
• W2007401421 hasConcept C2908647359 @default.
• W2007401421 hasConcept C2910240311 @default.
• W2007401421 hasConcept C501734568 @default.
• W2007401421 hasConcept C54355233 @default.
• W2007401421 hasConcept C63479239 @default.
• W2007401421 hasConcept C67705224 @default.
• W2007401421 hasConcept C75268714 @default.
• W2007401421 hasConcept C78458016 @default.
• W2007401421 hasConcept C86803240 @default.
• W2007401421 hasConcept C87590526 @default.
• W2007401421 hasConcept C8769409 @default.
• W2007401421 hasConcept C98638677 @default.
• W2007401421 hasConceptScore W2007401421C104317684 @default.
• W2007401421 hasConceptScore W2007401421C141231307 @default.
• W2007401421 hasConceptScore W2007401421C144024400 @default.
• W2007401421 hasConceptScore W2007401421C14500911 @default.
• W2007401421 hasConceptScore W2007401421C149923435 @default.
• W2007401421 hasConceptScore W2007401421C177606310 @default.
• W2007401421 hasConceptScore W2007401421C18903297 @default.
• W2007401421 hasConceptScore W2007401421C2779174946 @default.
• W2007401421 hasConceptScore W2007401421C2908647359 @default.
• W2007401421 hasConceptScore W2007401421C2910240311 @default.

• next