FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007402528> ?p ?o ?g. }

• W2007402528 endingPage "54" @default.
• W2007402528 startingPage "46" @default.
• W2007402528 abstract "Abstract MUC1, a heavily glycosylated mucin, has generated considerable interest as a target for tumor killing because of its overexpression in malignancies. Full‐length MUC1 (MUC1/TM) is proteolytically cleaved after synthesis generating α and β subunits, which specifically bind in a noncovalent interaction. Although the β chain remains on the cell surface, the α chain binds in an on‐and‐off interaction. Most anti‐MUC1 antibodies (Abs) described to date recognize epitopes within the highly immunogenic α‐chain tandem repeat. Because the α‐chain is shed, such Abs are sequestered and fail to reach MUC1‐expressing cells. Immunizing with cDNA encoding MUC1/TM and the spliced MUC1/X isoform from which the tandem repeat has been deleted yielded antibodies to the MUC1 α/β junction. Pseudomonas toxin PE38 linked to polyclonal anti‐MUC1 α/β junction Abs both bound and killed MUC1‐positive malignant cells. Monoclonal DMC209 binds the MUC1 α/β junction in both MUC1/X and MUC1/TM. When injected into SCID mice xenotransplanted with human breast cancer MDA‐MB‐231, monoclonal DMC209 showed significant in vivo tumor‐suppressive activity. The MUC1/X α/β junction presents a biologically‐significant target in MUC1‐expressing malignancies because ( i ) antibodies directed against cell‐bound α/β junction epitopes reach the intended cellular target, ( ii ) antibodies to junction epitope are internalized into cells, ( iii ) anti α/β junction antibodies can effectively kill high MUC1‐expressing cancer cells as antibody‐toxin conjugates and ( iv ) antibodies targeting the MUC1 cell‐bound α/β junction results in tumor suppression in vivo . Our results indicate that cell‐bound MUC1 α/β junction, unlike shed alpha chain, represents a highly effective moiety for targeting and killing MUC1‐expressing malignancies. © 2008 Wiley‐Liss, Inc." @default.
• W2007402528 created "2016-06-24" @default.
• W2007402528 creator A5015742671 @default.
• W2007402528 creator A5027096449 @default.
• W2007402528 creator A5036122175 @default.
• W2007402528 creator A5055579145 @default.
• W2007402528 creator A5067367280 @default.
• W2007402528 creator A5068679682 @default.
• W2007402528 creator A5071445059 @default.
• W2007402528 creator A5080920993 @default.
• W2007402528 date "2008-09-26" @default.
• W2007402528 modified "2023-10-15" @default.
• W2007402528 title "The MUC1 oncoprotein as a functional target: Immunotoxin binding to α/β junction mediates cell killing" @default.
• W2007402528 cites W1482788763 @default.
• W2007402528 cites W1522833171 @default.
• W2007402528 cites W1528931356 @default.
• W2007402528 cites W1965583673 @default.
• W2007402528 cites W1970732873 @default.
• W2007402528 cites W1973599688 @default.
• W2007402528 cites W1987555268 @default.
• W2007402528 cites W1989897633 @default.
• W2007402528 cites W1997571574 @default.
• W2007402528 cites W2001784904 @default.
• W2007402528 cites W2004801337 @default.
• W2007402528 cites W2008627281 @default.
• W2007402528 cites W2010427283 @default.
• W2007402528 cites W2025046214 @default.
• W2007402528 cites W2031564862 @default.
• W2007402528 cites W2033958784 @default.
• W2007402528 cites W2034102636 @default.
• W2007402528 cites W2034384208 @default.
• W2007402528 cites W2039893961 @default.
• W2007402528 cites W2043052307 @default.
• W2007402528 cites W2051084702 @default.
• W2007402528 cites W2054275272 @default.
• W2007402528 cites W2057309733 @default.
• W2007402528 cites W2062672501 @default.
• W2007402528 cites W2067126182 @default.
• W2007402528 cites W2076651050 @default.
• W2007402528 cites W2080631233 @default.
• W2007402528 cites W2080665774 @default.
• W2007402528 cites W2083249852 @default.
• W2007402528 cites W2089026770 @default.
• W2007402528 cites W2096186216 @default.
• W2007402528 cites W2108402832 @default.
• W2007402528 cites W2111527211 @default.
• W2007402528 cites W2134236935 @default.
• W2007402528 cites W2143566799 @default.
• W2007402528 cites W2150312232 @default.
• W2007402528 cites W2156087814 @default.
• W2007402528 cites W2162839084 @default.
• W2007402528 cites W2171617845 @default.
• W2007402528 cites W28705092 @default.
• W2007402528 doi "https://doi.org/10.1002/ijc.23910" @default.
• W2007402528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18821582" @default.
• W2007402528 hasPublicationYear "2008" @default.
• W2007402528 type Work @default.
• W2007402528 sameAs 2007402528 @default.
• W2007402528 citedByCount "20" @default.
• W2007402528 countsByYear W20074025282012 @default.
• W2007402528 countsByYear W20074025282014 @default.
• W2007402528 countsByYear W20074025282016 @default.
• W2007402528 countsByYear W20074025282017 @default.
• W2007402528 countsByYear W20074025282018 @default.
• W2007402528 countsByYear W20074025282019 @default.
• W2007402528 countsByYear W20074025282020 @default.
• W2007402528 countsByYear W20074025282021 @default.
• W2007402528 countsByYear W20074025282022 @default.
• W2007402528 crossrefType "journal-article" @default.
• W2007402528 hasAuthorship W2007402528A5015742671 @default.
• W2007402528 hasAuthorship W2007402528A5027096449 @default.
• W2007402528 hasAuthorship W2007402528A5036122175 @default.
• W2007402528 hasAuthorship W2007402528A5055579145 @default.
• W2007402528 hasAuthorship W2007402528A5067367280 @default.
• W2007402528 hasAuthorship W2007402528A5068679682 @default.
• W2007402528 hasAuthorship W2007402528A5071445059 @default.
• W2007402528 hasAuthorship W2007402528A5080920993 @default.
• W2007402528 hasBestOaLocation W20074025281 @default.
• W2007402528 hasConcept C115085202 @default.
• W2007402528 hasConcept C147483822 @default.
• W2007402528 hasConcept C153911025 @default.
• W2007402528 hasConcept C159654299 @default.
• W2007402528 hasConcept C195616568 @default.
• W2007402528 hasConcept C203014093 @default.
• W2007402528 hasConcept C2777421810 @default.
• W2007402528 hasConcept C542903549 @default.
• W2007402528 hasConcept C86803240 @default.
• W2007402528 hasConceptScore W2007402528C115085202 @default.
• W2007402528 hasConceptScore W2007402528C147483822 @default.
• W2007402528 hasConceptScore W2007402528C153911025 @default.
• W2007402528 hasConceptScore W2007402528C159654299 @default.
• W2007402528 hasConceptScore W2007402528C195616568 @default.
• W2007402528 hasConceptScore W2007402528C203014093 @default.
• W2007402528 hasConceptScore W2007402528C2777421810 @default.
• W2007402528 hasConceptScore W2007402528C542903549 @default.
• W2007402528 hasConceptScore W2007402528C86803240 @default.
• W2007402528 hasIssue "1" @default.
• W2007402528 hasLocation W20074025281 @default.

• next