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- W2007402693 abstract "We have measured whole blood concentrations and pharmacokinetics of propofol administered as a constant rate infusion during cardiac surgery. Ten patients undergoing elective cardiac surgery involving cardiopulmonary bypass (seven myocardial revascularization and three aortic valve surgery) received a continuous infusion of propofol 4 mg kg-1 h-1 to supplement alfentanil analgesia. Whole blood propofol concentrations were measured by high pressure liquid chromatography. A concentration greater than 1 microgram ml-1 was achieved within 15 min of starting the infusion and remained constant throughout surgery. Volume of distribution, clearance and terminal half-life were similar to those found in non-cardiac patients." @default.
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- W2007402693 date "1990-10-01" @default.
- W2007402693 modified "2023-09-27" @default.
- W2007402693 title "PHARMACOKINETICS OF AN INFUSION OF PROPOFOL DURING CARDIAC SURGERY" @default.
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- W2007402693 doi "https://doi.org/10.1093/bja/65.4.475" @default.
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