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• W2007402803 endingPage "4926" @default.
• W2007402803 startingPage "4922" @default.
• W2007402803 abstract "Translocations involving chromosome band 11q23, found in 5-10% of human acute leukemias, disrupt the ALL-1 gene. This gene is fused by reciprocal translocation with a variety of other genes in acute lymphoblastic and myelogenous leukemias, and it undergoes self-fusion in acute myeloid leukemias with normal karyotype or trisomy 11. Here we report an alteration of the ALL-1 gene in a gastric carcinoma cell line (Mgc80-3). Characterization of this rearrangement revealed a three-way complex translocation, involving chromosomes 1 and 11, resulting in a partial duplication of the ALL-1 gene. Sequencing of reverse transcription-PCR products and Northern blot analysis showed that only the partially duplicated ALL-1 gene was transcribed, producing an mRNA with exon 8 fused to exon 2. This report of ALL-1 gene rearrangement in a solid tumor suggests that ALL-1 plays a role in the pathogenesis of some solid malignancies. The absence of the normal transcript in this cell line, in association with the loss-of-heterozygosity studies on chromosome 11q23 seen in solid tumors, suggests that ALL-1 is involved in tumorigenesis by a loss-of-function mechanism." @default.
• W2007402803 created "2016-06-24" @default.
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• W2007402803 date "1995-05-23" @default.
• W2007402803 modified "2023-09-29" @default.
• W2007402803 title "Involvement of the ALL-1 gene in a solid tumor." @default.
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• W2007402803 doi "https://doi.org/10.1073/pnas.92.11.4922" @default.
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